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Kidney Week

Abstract: FR-PO1164

Effect of a Good Oral and Dental Care on Inflammation and Oral Lesions in Renal Transplant Patients

Session Information

Category: Transplantation

  • 1902 Transplantation: Clinical

Authors

  • Sharma, Raj K., Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
  • Sharma, Lokesh, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow, India
  • Mehrotra, Sonia, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
  • Pradhan, Devina, Rama Dental College Hospital & Research Centre, Lucknow, India
Background

Inflammation plays an important role in causing complications in CKD and transplant
patients. C-reactive protein and pro-inflammatory cytokines could predict outcomes in
transplant patient. Poor oral health results in inflammation and cytokine production.
There is need to evaluate the benefit of good oral hygiene on renal transplant outcome.

Methods

A randomized controlled trial was carried out amongst CKD patients going for renal
transplantation. All patients had dental and oral examination (Type III clinical
examination as per American Dental Association specifications and WHO oral health
proforma, 2013)
Group I (Non interventional group) 50 patients. Group II (Intervention group) - 50 patients
of chronic kidney disease going for transplantation. Group III (Control group) comprised
of 50 healthy age, sex matched subjects. Intervention group followed regular tooth
brushing, use of dental floss along with use of mouth wash twice every day and
counseling sessions for good oral and dental care for a period of 3 months after
transplant. Non-intervention group continued usual oral and dental care.
The oral and dental findings specially the periodontitis score was compared
between groups I and II and with the healthy controls. CRP (C- reactive protein) values
were assayed at baseline and after 3 months.

Results

Comparison of CRP values between Interventional and non-interventional groups at
baseline and at 3months showed that periodontitis score and CRP significantly came
down at 3 months in intervention group as compared to non- intervention group . CRP
values in the interventional and non-intervention groups were analyzed in relation to
presence of donor specific antibodies (DSA) and HLA mismatch scores in the two
groups. Our data shows that after aggressive dental and mouth hygiene routine,
intervention group patients showed significant decline in CRP values as compared to the
non intervention group. It almost reached close to values in normal controls.

Conclusion

The present study concludes that the oral hygiene of the patients with chronic
kidney disease going for transplant is deteriorated. Good oral and dental care in
transplant recipients can improve inflammation which could have beneficial effect on
post transplant outcomes "