Abstract: SA-PO811
Higher Fruit Intake Is Associated with Albuminuria in a Nested United Kingdom Biobank Case Control Cohort
Session Information
- Health Maintenance, Nutrition, Metabolism - II
November 09, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Health Maintenance, Nutrition, and Metabolism
- 1300 Health Maintenance, Nutrition, and Metabolism
Authors
- McKay, Gareth J., Queen's University Belfast, Belfast, United Kingdom
- Paterson, Euan Neil, Queen's University Belfast, Belfast, United Kingdom
- Maxwell, Alexander P., Queen's University Belfast, Belfast, United Kingdom
Background
Fruit and vegetable (F&V) consumption is associated with better renal function and lower risk of CKD. These associations may be explained by the protective effects of antioxidant vitamins and phytonutrients, nitric oxide precursors, and other active substances present in F&V. The potential negative consequences of increased fruit intake on renal health however have not been extensively studied. Fruit is an important dietary source of the monosaccharide fructose that has been implicated as an environmental toxin contributing to gout, acute kidney injury and chronic kidney disease. This study evaluated associations between F&V consumption and albuminuria in the United Kingdom Biobank (UKBB www.ukbiobank.ac.uk).
Methods
A nested case-control design included cases defined by urinary albumin to creatinine ratio (ACR) ≥ 3mg/mmol and controls with ACR < 3mg/mmol, matched for age, sex and ethnicity. Typical daily F&V intake was assessed by touch screen food frequency questionnaire. Associations between fruit, vegetable or F&V intake and ACR were tested using binary logistic regression adjusted for potential confounders age, sex, ethnicity, systolic blood pressure (SBP), diabetes, smoking, blood pressure medication, waist circumference and alcohol consumption.
Results
In a sample of 6998 participants (3499 case-control pairs), the mean age was 59 years (standard deviation [SD] 8), 53% were female, and 86% were white. SBP was 150 mmHg (SD 22) for cases and 144 mmHg (SD 20) for controls (24% of cases and 16% of controls used BP lowering medication). Twice as many cases (16%) had diabetes compared to controls.
In adjusted models, no significant association was found between vegetable intake and ACR. Greater fruit, and combined F&V intake, were significantly associated with ACR ≥ 3mg/mmol (fruit: odds ratio [OR] = 1.03, 95% confidence intervals [CI]: 1.01, 1.05; P = 0.005; Combined F&V intake: OR = 1.02, CI: 1.00, 1.03; P = 0.01).
Conclusion
In the UKBB population, vegetable intake alone was not significantly associated with albuminuria. However, increased fruit intake was significantly associated with a greater risk of albuminuria. These findings are consistent with previous associations between fructose intake and renal damage.
Funding
- Government Support - Non-U.S.