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Kidney Week

Abstract: TH-PO831

Simplification of Total Kidney Volume Measurement Procedures for ADPKD

Session Information

Category: Genetic Diseases of the Kidneys

  • 1001 Genetic Diseases of the Kidneys: Cystic

Authors

  • Mansoori, Ziba, UCSF, San Francisco, California, United States
  • Swarnakar, Vivek, UCSF, San Francisco, California, United States
  • Park, Meyeon, UCSF, San Francisco, California, United States
Background

Total kidney volume (TKV) is an important measure of risk of disease progression in autosomal dominant polycystic kidney disease (ADPKD). Methods to measure TKV are labor-intensive and time-consuming, and not all centers have ability to measure TKV. We developed a technique to provide timely and reliable quantification of TKV using any sequence of abdominal magnetic resonance imaging (MRI).

Methods

Abdominal MRI scans of 74 consecutive patients from the UCSF Polycystic Kidney Disease Center of Excellence were selected. The technique was developed using functionality readily available in an FDA-approved commercial medical imaging analysis software (Ziosoft). Scans for the subjects were acquired from different scanner types (GE, Phillips) and field strengths (1.5 T, 3 T). On each scan the volumes of left and right kidneys were assessed. Measurements were done on coronal T2-weighted DICOM images (single shot fast spin echo/half-Fourier, slice thickness between 3 and 9 mm). The outer kidney contour was defined manually by tracing on each slice. The contour from each 2D slice was merged to create a true 3D volume of the kidney. The process is calibrated using parameters available in DICOM images. For some cases the cystic volume was measured for each kidney as well via a binary intensity value thresholding. The non-cystic volume was determined by digital subtraction of cystic volume from total kidney volume.

Results

Average time to implement these measures on standard non-contrast MRI sequence was 30 minutes. Comparing the TKV to measurements obtained by alternative methodology (reported by prior institutions on the same scans) revealed a concordance of > 90%.

Conclusion

Our technique is readily applicable to routine MRI images obtained for clinical purposes in ADPKD patients. Use of this technique may improve risk stratification availability for ADPKD patients.

3D volume rendering; cysts green.