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Abstract: TH-PO1035

Biopsy Proven Diagnosis of CKD in Sub-Saharan Africa: An H3 Africa Cohort Study

Session Information

Category: Glomerular Diseases

  • 1203 Glomerular Diseases: Clinical, Outcomes, and Trials

Authors

  • Mamven, Manmak, The University of Arizona, Tucson, Arizona, United States
  • Ilori, Titilayo O., The University of Arizona, Tucson, Arizona, United States
  • Okoye, Ogochukwu Chinedum, Delta State University Teaching Hospital, Oghara, Nigeria
  • Parekh, Rulan S., The Hospital For Sick Children, Toronto, Ontario, Canada
  • Hodgin, Jeffrey B., The University of Michigan, Ann Arbor, Michigan, United States
  • Gbadegesin, Rasheed A., Duke University Medical Center, Durham, North Carolina, United States
  • Kumar, Shikhar, The University of Arizona, Tucson, Arizona, United States
  • Ojo, Akinlolu O., The University of Arizona, Tucson, Arizona, United States
  • Adu, Dwomoa, University of Ghana, Accra, Ghana

Group or Team Name

  • H3 Africa Kidney Disease Research Network
Background

Chronic kidney disease is increasingly prevalent in Sub-Saharan Africa (SSA) and a major factor leading to increased morbidity and mortality. Treatment of CKD, specifically glomerulonephritis (GN) is paramount to reducing CKD progression, morbidity and mortality, however, little is known about the types and incidence of primary glomerulonephritis (GN) nor is pathological diagnosis feasible throughout SSA.

Methods

Among 500 native kidney biopsies performed so far at 10 centers across Africa, we assessed patterns and types of glomerular disease in participants with eGFR greater than 15mls/minute enrolled in the H3 Africa Kidney Disease network cohort study from 2017-2019. Biopsies were performed with real time ultrasound guidance and samples were shipped for processing and evaluation of light, immunofluorescence and electron microscopy by 2 US pathologists. We present preliminary results on demographic, clinical and biopsy data obtained.

Results

Demographics and baseline characteristics: The mean age was 30.68 ± 13.12 years, there were 231 males(50.4%), 357 (77.95%) patients were Nigerians, 99 (21.62%) and were Ghanaians. The mean eGFR was 66.27 ± 37.20. 10 (9.17%) had high blood pressure, 11 (2.43%) had diabetes, 6 (1.32%) were hepatitis B positive and 1 (0.22%) was positive to hepatitis C.

Conclusion

FSGS, membranous nephropathy and minimal change disease were the most frequent primary glomerulonephritis among adults in our region. Lupus Nephritis is a common secondary GN in Sub Saharan Africa.

Types and patterns of biopsy-proven Glomerulonephritis

Funding

  • NIDDK Support