Kidney Week

Abstract: TH-PO704

Distribution of Myocardial Fibrosis by Native T1 Times Using Cardiac Magnetic Resonance Measurements in CKD

Session Information

• Hypertension and CVD: Epidemiology, Risk Factors
  November 07, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Hypertension and CVD

• 1401 Hypertension and CVD: Epidemiology, Risk Factors, and Prevention

Authors

• Fares, Anas, University Hospitals Cleveland Medical Center, Cleveland, Ohio, United States

Anas Fares,

• Hill, Eddie, University Hospitals, Cleveland Heights, Ohio, United States

Eddie Hill,

• Kalisz, Kevin, Northwestern University, Chicago, Illinois, United States

Kevin Kalisz,

• Vergara-Martel, Armando, University Hospitals Cleveland Medical Center, Cleveland, Ohio, United States

Armando Vergara-Martel,

• Rajagopalan, Sanjay, University Hospitals, Cleveland Heights, Ohio, United States

Sanjay Rajagopalan,

• Dobre, Mirela A., Case Western Reserve University, Cleveland, Ohio, United States

Mirela A. Dobre,

Background

Previous evidence suggests that native myocardial T1 relaxation times assessed by cardiac magnetic resonance imaging (MRI) are relevant biomarkers of the extension and severity of myocardial fibrosis in patients with chronic kidney disease (CKD). However, detailed classification and cutoffs of the T1 values in correlation with the severity of kidney disease have not been described

Methods

A cohort of 51 patients with eGFR>20 ml/min/1.73m² and without congestive heart failure underwent concomitant assessment of kidney function and noncontrast cardiac MRI using T1 mapping sequence technique in a 3T scanner. CKD was defined as eGFR<60 ml/min/1.73m2. T1 times were measured in all myocardial segments using the American Heart Association 16-segment method and utilizing an advanced post processing software.Student t tests and multivariate linear regression analyses were performed to test the association of CKD with segmental T1 times.

Results

51 patients were enrolled in the study. Global T1 values in individuals with (eGFR<60) and without (GFR≥60) CKD were 1045.91 ±42.74ms and 1019.75±47.16ms (,p=0.02), respectively. T1 values for anteroseptal, anterior, and inferoseptal segments were 1083.33± 38.53ms and 1049.03±49.81ms(p=0.001), 1052.29±51.81ms and 1021.41±47.52ms (p= 0.01), 1061±40.61ms and 1016.4±60.06ms (p<0.001), in CKD and non CKD patients respectively. Basal T1 values were 1062.93±34.55ms and 1030.56±45.41ms (p<0.001) respectively. In models adjusted for demographics, co-morbidities, medications and eGFR, age was the only variable significantly associatiated with global T1 times.

Conclusion

Cardiac MRI T1 relaxation times can be surogate markers to risk stratify patients with CKD. The cardiac fibrosis in CKD is more prevalent in the basal, anterior and septal myocardial segments.

Funding

• Other NIH Support