Kidney Week

Abstract: TH-PO383

Prognostic Score for Chronic Renal Disease in Patients with Lupus Nephritis

Session Information

• CKD: Risk Scores and Translational Epidemiology
  November 07, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

• 2101 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

• Perez, Myriam K., Hospital General de México Dr. Eduardo Liceaga, México, Mexico

Myriam K. Perez,

• Diaz villar, Jineth Leidy, Hospital General de México Dr. Eduardo Liceaga, México, Mexico

Jineth Leidy Diaz villar,

• Cordoba hurtado, Angela Maria, Universidad Nacional Autonoma de Mexico, Ciudad de Mexico, Mexico

Angela Maria Cordoba hurtado,

• Perez-Navarro, L. Monserrat, Hospital General de México Dr. Eduardo Liceaga, México, Mexico

L. Monserrat Perez-Navarro,

• Soto, Virgilia, INC Ignacio Chavez, Mexico City, Mexico

Virgilia Soto,

• Valdez-Ortiz, Rafael, Hospital General de México Dr. Eduardo Liceaga, México, Mexico

Rafael Valdez-Ortiz,

Group or Team Name

• M

Background

There is currently a prognostic score of progression to chronic kidney disease (CKD) in patients with lupus nephritis (LN), this tool evaluates: cellular and fibrous crescents; activity and chronicity index; glomerular sclerosis; interstitial fibrosis; nephrotic syndrome and glomerular filtration rate. The resulting data divides the population at low risk; moderate; and severe risk. The objective of this study was to apply this score to Mexican patients with LN and to predict their progression to CKD.

Methods

Study of ambilective cohort of patients with NL of the HGM from August 2012 to August 2017, in which the prognostic score was applied. Descriptive statistics and survival analysis were performed with Cox regression, with 95% CI, considered a value of p <0.05 as statistically significative.

Results

141 patients were analyzed; we found a mean age of 32.01±10.95 years, 73% (103) women. According to the ISN/RPS class IV (38%) and class IV+V (34%) were identified and classes II, III, III+IV and V were presented with frequency of 11% or less. The score stratified 54% (76) patients in the low risk; 43% (60) moderate; and 3% (4) severe. During the follow-up at 6 months, 29 patients (26%) presented total remission (RT); 42% (48) partial remission (PR); and 32% (36) without remission (SR). Progression to CKD was observed in 19% of patients with (RT), in 37% with (RP) and in 44% (SR), (p <0.05). For terminal CKD (ERCT) no significant differences were observed (patients with RT 20%, RP 27% and SR 53%, p = 0.15). According to the score, 15 (22%) of the patients with low risk presented progression to CKD, unlike 33 (73 %) of those with moderate risk, and 4 (100%) with high risk (p <0.001). Progression to ERCT was observed in 3 (4%) patients with low risk, 27 (45%) moderate risk and 1 (20%) patient with high risk (p <0.001).

Conclusion

The results show that the application of this prognostic score in Mexican patients with LN is useful to predict the progression to CKD and ESRD regardless of the response to treatment.