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Kidney Week

Abstract: INFO12-TH

George M. O'Brien Kidney Center at Yale

Session Information

  • Informational Posters - I
    November 07, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
    Abstract Time: 10:00 AM - 12:00 PM

Category: Genetic Diseases of the Kidneys

Author

  • Aronson, Peter S., Yale School of Medicine, New Haven, Connecticut, United States
Description

The goal of the O’Brien Kidney Center at Yale is to facilitate translational and clinical research that will advance the prevention and treatment of kidney diseases. The Yale O’Brien Center provides investigators with access to specialized core services not otherwise routinely available to support their research:

1. Animal Physiology and Phenotyping Core. Director: Patricia Preisig.
The Core provides specialized services and training for assessing renal function and blood pressure in small animals. Its services include clearance studies and GFR measurements in anesthetized animals, perfusion fixation for histology studies, serum and urine electrolyte and creatinine assays, blood gas acid-base parameters, balance studies in metabolic cages, circadian rhythm studies in light-tight caging, acute blood pressure measurements in anesthetized mice, and chronic awake blood pressure measurements by radiotelemetry.

2. Disease Models and Mechanisms Core. Co-Directors: Stefan Somlo, Lloyd Cantley.
The Core provides users with ready access to unique mouse models, associated cell line resources, and advanced human translational technologies. Its services include bacterial artificial chromosome (BAC) recombineering and transgenesis, support for CRISPR/Cas9 genome editing for mouse line production, support for kidney cell line production using RosaDTRfl/fl (Terminator) mice, and development of Imaging Mass Cytometry for spatially-preserved analysis of human kidney biopsy samples.

3. Human Genetics and Clinical Research Core. Co-Directors at Yale: F. Perry Wilson, Shrikant Mane, Stefan Somlo. Co-Director at Johns Hopkins: Chirag Parikh.
The Core provides services and training to enhance translational studies in kidney disease. Its services include patient DNA extraction and archiving, high throughput SNP genotyping, whole exome capture and sequencing, additional next generation sequencing technologies, and bioinformatics support. Its clinical research services include protocol development, patient recruitment, sample processing, biobanking, access to archived samples from NIH studies, multiplex assays for biomarkers, extraction and analysis of electronic health record data, and biostatistical support.

In addition, pilot grants for junior investigators and summer research fellowships for undergraduate and medical students are available.

Please access the Center website for additional information: http://obriencenter.yale.edu

Funding

  • NIDDK