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Kidney Week

Abstract: INFO05-TH

The Kidney Precision Medicine Project (KPMP)

Session Information

  • Informational Posters - I
    November 07, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
    Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

Authors

  • Himmelfarb, Jonathan, Kidney Research Institute, Seattle, Washington, United States
  • Kretzler, Matthias, U.Michigan, Ann Arbor, Michigan, United States
  • Iyengar, Ravi, Icahn School of Medicine at Mount Sinai, New York, New York, United States

Group or Team Name

  • and the KPMP Consortium
Description

The Kidney Precision Medicine Project (KPMP) is a National Institute of Diabetes and Digestive and Kidney Diseases funded consortium that aims to better understand and treat human kidney diseases. The goals of KPMP are to ethically and safely obtain kidney biopsies from participants with diagnosed acute kidney injury (AKI) or chronic kidney disease (CKD), to find disease subgroups to better stratify kidney disease patients, to identify critical cells pathways and targets for novel therapies, and to create a kidney tissue atlas.

Currently, 24 sites make up the consortium, including eight sites that will serve as AKI or CKD recruitment & biopsy centers for the study, and six multi-site tissue interrogation centers that will analyze the biopsy tissues through a combination of imaging, transcriptomic, proteomic and metabolomic technologies. Coordination of study activities is led by several sites in a federated Central Hub. Central Hub responsibilities include administrative organization, data coordination, integration and visualization. Patient engagement is paramount to the work of the consortium; kidney patients advise on study activities by serving on the KPMP Community Engagement Committee, as well as nearly all other consortium committees, including the Steering Committee.

KPMP aims to serve as a publicly available resource to both research and lay communities. The KPMP website www.kpmp.org is a gateway to access all study resources, including protocols and the kidney tissue atlas. Data will be made available to the research community immediately after validation. Funded collaboration opportunities are periodically available through RFAs on the study website.

Funding

  • National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK