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Kidney Week

Abstract: INFO08-TH

NUGoKidney Research Cores: Paving the Way for Breakthroughs in Kidney Therapeutics

Session Information

  • Informational Posters - I
    November 07, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
    Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

Authors

  • Quaggin, Susan E., Northwestern University, Chicago, Illinois, United States
  • George, Alfred L., Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
  • Isakova, Tamara, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
  • Wertheim, Jason, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
  • Schnaper, H. William, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
  • Judge, Sheila M., Northwestern University, Chicago, Illinois, United States
  • Scott, Evan, Northwestern University, Chicago, Illinois, United States
  • Sipocz, Ashley, Northwestern University George M. O''Brien Kidney Research Core Center, Chicago, Illinois, United States
  • Alvarez, Angel, Northwestern University, Chicago, Illinois, United States
Description

Funded by the National Institute of Diabetes and Digestive and Kidney Diseases in 2018, the Northwestern University George M. O’Brien Kidney Research Core Center (NUGoKIDNEY) supports innovative research and cross-cutting collaborations between basic and clinical scientists to advance the discovery of novel therapeutics for patients with kidney diseases. NUGoKidney has had a productive first year, establishing a robust infrastructure characterized by strong communications, coordination, and integration across all Center components.

The Center unites investigators across three Cores: Pre-Clinical Models Core (A), Therapeutics Design and Development Core (B), and Clinical and Translational Core (C). Core A offers resources and consultation services to develop state-of-the-art preclinical kidney disease models to identify and test new therapeutic targets. This includes access to over 30 in-house mouse genetic models, concierge genome editing services, and services enabling generation of induced pluripotent stem cells from patients with kidney diseases. Core B brings together the expertise and cutting-edge techniques of Northwestern’s research infrastructure to offer centralized consultation and services focused on nephro-therapeutics development and spans concept and design of small molecular drugs and therapeutic cells through in vitro validation and small animal testing. Core C provides a centralized environment, essential resources and multi-disciplinary expertise to safely and ethically translate and target therapeutic discoveries into the right patient population.

All cores established infrastructure this year and are already providing services to users within and outside of NU. Each core’s work has been greatly facilitated by the launch of a Center web portal (nephroHUB.org) where users can access core resources and a centralized online request process.

NUGoKIDNEY also includes Pilot and Feasibility and Enrichment Programs. The Pilot and Feasibility Program funded three pilot projects in year 1 and recently closed year 2 applications. The Enrichment Program hosted its first cohort of high school students for its SciHigh Summer Program, which mentors highly motivated students from underrepresented/underserved communities to prepare for biomedical careers.

Funding

  • Research presented in this abstract was supported by George M. O’Brien Kidney Research Core Center (NU GoKidney), which is generously supported by the award P30 DK114857 from the National Institute of Diabetes and Digestive and Kidney Diseases, within the National Institutes of Health.