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Kidney Week

Abstract: INFO17-SA

The Swiss Kidney Stone Cohort: A Longitudinal, Multicentric, Observational Cohort of Stone Formers in Switzerland

Session Information

  • Informational Posters - III
    November 09, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
    Abstract Time: 10:00 AM - 12:00 PM

Category: Bone and Mineral Metabolism


  • Bonny, Olivier, Lausanne University Hospital , Lausanne, Switzerland
  • Fuster, Daniel G., Bern University Hospital, Bern, Be, Switzerland
  • Seeger, Harald, University Hospital Zurich, Zurich, Switzerland
  • Ernandez, Thomas, University Hospital of Geneva, Geneva, Switzerland
  • Buchkremer, Florian, Kantonsspital Aarau, Aarau, Switzerland
  • Dhayat, Nasser, Inselspital Bern, Bern, Switzerland
  • Ritter, Alexander, University Hospital Zurich, Zurich, Switzerland
  • Roth, Beat, Department of Urology, University of Bern, Switzerland, Bern, Switzerland
  • Wagner, Carsten A., University of Zurich, Zurich, ZH, Switzerland

The Swiss Kidney Stone Cohort (SKSC) is a longitudinal multicentric observational cohort of stone formers, aiming at fostering research on kidney stones and at collecting epidemiological data and biological samples from stone formers.
The SKSC was launched in 2014 and involves the five university centers and one State hospital covering most of Switzerland. The investigation protocol is identical in all recruiting centers. At baseline, patients collect two consecutive 24 hour urines and complete a 2 day food diary that helps answering two 24h structured recall interviews performed by trained dieticians using the software Globodiet. Validated food frequency and physical activity questionnaires are also filled. Fresh morning urine is examined for crystalluria. Biological samples (2x24h urine and blood) are analyzed centrally and biobanked. DNA is extracted and stored. Based on this initial baseline evaluation, patients are given either nutritional counsels (by nephrologists or by dedicated dieticians) and/or are treated with specific drugs appropriate to their condition. A follow-up visit at 3 months (blood and 1x24h urine are collected) provide evidence of adherence to the proposed intervention and allows further therapeutic refinement. Further annual follow-ups during 3 years (blood and 2x24h urine collections) are meant to boost adherence, check for cardiovascular and metabolic risk factors over time and allow evaluation of the remaining stone burden. Then, follow-up phone calls every other year is continued for up to 10 years in order to keep track of stone and/or cardiovascular events. On June 2019, 782 patients have been included in the SKSC.
Started in 2018, a control group of 250 matched-for-age-and-sex-individuals without kidney stone (as demonstrated by native abdominal CT-scan) completes the study by offering data collected with the exact same protocol on non-stone formers.
SKSC is open to researchers interested in kidney stones. Its strengths uncover strong nutritional phenotype, longitudinal follow-up and standardized protocols coupled to biobanking. SKSC sets the stage for further clinical interventional trials or for basic genetic, molecular or –omics studies.
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  • The Swiss National Science Foundation through the special program "National Centers of Competence in Research KIDNEY.Control of HOMEOSTASIS"