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Kidney Week

Abstract: INFO05-SA

GUDMAP: The Genitourinary Development Molecular Anatomy Project

Session Information

  • Informational Posters - III
    November 09, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
    Abstract Time: 10:00 AM - 12:00 PM

Category: Development, Stem Cells, and Regenerative Medicine

Author

  • Valerius, M. Todd, Brigham and Women's Hospital, Boston, Massachusetts, United States

Group or Team Name

  • The GUDMAP Consortium
Description

The GenitoUrinary Development Molecular Anatomy Project (GUDMAP) is an open access online resource developed by a consortium of laboratories working to provide the scientific and medical community with transcriptomic and protein expression data, transgenic mice, high-resolution 2D and 3D morphological data, and tools to facilitate research and teaching in genitourinary (GU) development. The goal is to stimulate further research into the genitourinary system by identifying novel cell types and gene expression domains in the kidneys, ureters, bladder, prostate, urethra, external genitalia, and associated reproductive structures and accompanying innervation. The GUDMAP database includes data from large-scale in situ hybridization screens, RNA-seq and scRNA-seq and microarray gene expression data, ChIP-seq, 3D Optical Projection Tomography (OPT) images, nanoscale computed tomography (nanoCT) image volumes, immunofluorescence, and high-resolution histology of the developing mouse and human GU system. Beyond tissue structures, GUDMAP includes characterization of nociceptors and associated cell types in pain processing of the murine urinary tract and pelvic region. Expression data and histological samples are annotated using a high-resolution ontology specific to the GU system. The database is searchable by gene name, function, or anatomical structure, leading users to available annotated datasets including scRNA-seq data. GUDMAP initially focused on the murine GU system, but now has expanded to include gene expression and morphological data on the human GU and reproductive tract development. GUDMAP data are curated and accessible at www.gudmap.org.

Funding

  • GUDMAP is supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).