ASN's Mission

ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005

email@asn-online.org

202-640-4660

The Latest on Twitter

Kidney Week

Abstract: INFO16-FR

Investigating the Prevalence of CKD of Unknown Etiology (CKDu) in a Rural Area of Bangladesh

Session Information

  • Informational Posters - II
    November 08, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
    Abstract Time: 10:00 AM - 12:00 PM

Category: Educational Research

Authors

  • Iqbal, Md Masud, SSMC, Dhaka, Bangladesh
  • Chowdhury, Md ayub ali, National Institute of Kidney Disease & Urology, Dhaka, Bangladesh

Group or Team Name

  • Kidney Disease Research Group (KDRG)
Description

Background: Over the last two decades it is found that a large number of patients develop CKD, especially in rural communities that remain unexplained despite extensive clinical and laboratory workup. This form of CKD that is not associated with known risk factors or a specific histological diagnosis hence it has been termed CKD of unknown etiology (CKDu).
Objective: In this proposed study it is aimed to investigate whether chronic Kidney Disease of unknown etiology involves significant number of rural population.
Methods: Study type and time: This is a longitudinal study and will be conducted in 2019-20.
Study population: All adult people ≥ 40 years living in a rural area
Study area: An administrative area named Baidyerbazar union of Sonargaon upzila of Narayanganj district in Bangladesh. Among 23035 populations, 11658 are male and 11377 are female.
Sample size: Prevalence of CKD is taken as 10%. Taking same number of male and female , considering 90% household eligibility rate, 95% household screening rate, 98% household response rate, 98% individual eligibility rate, 85% individual response rate and 30% drop out; total the sample is 454
Sampling technique: Simple random sampling technique will be adopted. After selection of a patient, his/her detail clinical history and records of medical data will be collected and a data collection sheet will be filled up. Relevant investigations will be done.
Variables: Clinical variables-Socio demographics characteristics, history of pre-existing diseases; hypertension, diabetes, CKD, Kidney stone. Drug history: nephrotoxic drugs, NSAIDs, herbal drugs. Exposure to pesticides and fertilizers. Drinking water source (river/ pond/ tube well/ tap/ well).History of infectious diseases: hepatitis B, C. History of snake bite
Laboratory variables- Serum creatinine, cystatin C, eGFR, Urine ACR, Fasting blood glucose, Urine R/M/E, Ultrasound Imaging of kidneys, C3, ANF and finally in some for confirmation renal biopsy (If CKD with normal size kidney)
Statistics: All data will be entered in SPSS software, rechecked and analyzed
Conclusion: It is expected that prevalence of CKDu could be around 10-20% of total identified ckd population.

Funding

  • Multiple funding sources ( governmental and nongovernmental research supports)