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Abstract: TH-PO1194

Effects of Exercise Training on Psychosocial Health and Cognition in Elderly Hemodialysis Patients

Session Information

Category: Dialysis

  • No subcategory defined

Authors

  • Chan, Khin N., VA Palo Alto Health Care System/Stanford University, Palo Alto, California, United States
  • Rabkin, Ralph, VA Palo Alto Health Care System/Stanford University, Palo Alto, California, United States
  • Chen, Yu, VA Palo Alto Health Care System/Stanford University, Palo Alto, California, United States
  • Nagare, Atul Anandrao, VA Palo Alto Health Care System, Palo Alto, California, United States
  • Niu, Tieming, VA Palo Alto Health Care System/Stanford University, Palo Alto, California, United States
  • Lit, Yiming, VA Palo Alto Health Care System/Stanford University, Palo Alto, California, United States
  • Kurella Tamura, Manjula, VA Palo Alto Health Care System/Stanford University, Palo Alto, California, United States
  • Myers, Jonathan N., VA Palo Alto Health Care System/Stanford University, Palo Alto, California, United States
Background

The impact of exercise training on health-related quality of life (HRQOL) and cognition in chronic kidney disease has not been fully explored. We aimed to determine the effects of 12-weeks of home-based exercise training on psychosocial health and cognition outcomes among elderly maintenance hemodialysis (MHD) patients.

Methods

Fifty-six patients (66± 7 years; exercise [Ex]: n=28, usual care [UC]: n=28) with end-stage renal disease on MHD (mean years of MHD: 4±4; mean Kt/V=2.1) were studied using the SF-36 v2, Kidney Disease and Quality of Life (KDQOL) and a battery of cognitive function tests as part of a randomized trial. Ex subjects underwent a home-based aerobic and resistance training program for 12 weeks. Eight components of the SF-36 v2 (bodily pain, general health, mental health, physical functioning, role physical, role emotional, social functioning, vitality), and 5 components of the KDQOL (burden of kidney disease, symptoms, effects, physical component score [PCS], and mental component score [MCS]) were assessed. Tests of cognitive function assessing general cognition, executive function, memory and verbal learning were obtained.

Results

Ex patients improved peak VO2 by 11% (p=0.01), while no differences were observed among UC. A 20-point increase in general health was observed among Ex (p=0.04), and trends were observed for increases in physical functioning and role emotional (p=0.08). No other HRQOL measures differed between EX and UC patients. KDQOL symptoms improved in Ex (p=0.05). PCS increased slightly from 38% ± 12 to 45% ± 10 (p=0.12) in EX. KDQOL measures were unchanged in UC. There were no significant changes in cognition within or between groups.

Conclusion


Home-based exercise training promotes health-related quality of life and some symptom metrics but did not affect cognition.

Funding

  • Veterans Affairs Support