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Abstract: TH-PO1212

Water Intake and Blood Pressure in Children: Results from the SPA Project

Session Information

Category: Hypertension and CVD


  • Ardissino, Gianluigi, Center for HUS Prevention, Control and Management, Milano, Italy
  • Perrone, Michela, Pediatric Nephrology and Dialysis Unit, Milano, Italy
  • Ghiglia, Silvia A.c., Fondazione Ca' Granda Osp. Maggiore Policlinico, Milano, Italy
  • Salice, Patrizia, Fondazione Ca' Granda Osp. Maggiore Policlinico, Milano, Italy
  • Tel, Francesca, Fondazione Ca' Granda Osp. Maggiore Policlinico, Milano, Italy
  • Capone, Valentina, Fondazione Ca' Granda Osp. Maggiore Policlinico, Milano, Italy
  • Piantanida, Sandra, Polo Materno Infantile- Ospedale F. del Ponte - Varese, Comerio, Italy
  • Di michele, Silvia, UOC Pediatria Ospedale di Pescara, Pescara, Italy

Group or Team Name

  • SPA Project

Sodium (Na) intake (I) is involved in the development of hypertension (HPT); to reduce NaI is important in the treatment of HPT, but also the increase in renal Na excretion (E) might be a potential preventive and/or therapeutic opportunity. The SPA Project studied blood pressure (BP) in relation to water (H2O) and NaI with the working hypothesis that an increased H2O I can improve renal Na handling.


339 healthy, non-overweight children (166 girls), 5.7 years old (IQR: 5.3-6.2) were characterized for: BP (using standardized multiple office BP measurement), Na and H2O I (by means of urinary Na and creatinine from 4 samples taken in 4 days). After categorizing subjects as low/high Na I and low/high water I (based on median value), BP was compared.


Among children with higher NaI, those introducing more H2O, showed a significantly (p<0.001) lower BP (both systolic and diastolic) compared to those who drink less (fig.). This difference was not observed among children with lower NaI.


Our findings support the hypothesis that an increased H2O I, reduces BP perhaps by increasing Na renal E. We speculate that this simple, highly acceptable, inexpensive and harmless measure might have a role in preventing and minimizing the epidemics of HPT and related morbidities.


  • Private Foundation Support