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Abstract: PO2046

Dysbiosis of Gut Microbiota in Adult Idiopathic Membranous Nephropathy with Nephrotic Syndrome

Session Information

Category: Health Maintenance, Nutrition, and Metabolism

  • 1300 Health Maintenance, Nutrition, and Metabolism

Author

  • Zhang, Jun, Division of Nephrology, Department of medicine, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
Background

Gut bacterial microbiota is altered in patients with chronic kidney disease (CKD) and those on dialysis. However, it is not yet clear what bacterial composition changes occur in patients with idiopathic nephrotic syndrome. We present in this report the changes in gut bacterial microbiota in idiopathic nephrotic syndrome patients with membranous nephropathy.

Methods

A total of 158 individuals were recruited for this study. Of these, 80 were CKD3–5 stage patients without nephrotic syndrome, 48 patients had idiopathic nephrotic syndrome and pathological diagnosis of membranous nephropathy, and 30 were age- and sex-matched healthy controls. The gut microbiome composition was analyzed using a 16S ribosomal RNA gene-based sequencing protocol.

Results

The results indicate that the nephrotic syndrome (NS) patients had a significantly different alpha and beta diversity compared with the CKD3–5 group and healthy controls (p < 0.01). At the phylum level, the NS patients showed increased Fusobacteria and Proteobacteria but reduced Firmicutes when compared with the healthy controls. At the genus level, Megamonas, Megasphaera, Akkermansia, and the butyrate-producing bacteria Lachnospira, Roseburia, and Fusobacterium were more abundant in the controls (LDA score > 3) than the CKD3–5 and NS patients. Compared with the healthy controls, we found that Parabacteroides was increased in CKD3–5 and NS patients. In addition, Oscillospira and Ruminococcus were more abundant in CKD patients than in the other two groups (LDA score > 3). At the genus level, ten bacterial taxa were more prevalent in the healthy controls. Providencia and Myroides were more prevalent in NS patients.

Conclusion

Our findings highlight that, NS patients had a significantly different alpha and beta diversity and decreased gut microbiota-derived short-chain fatty acids, such as butyrate. However, large-scale prospective studies should be performed to identify the cause and effect factors of these changes in the microbiota in NS patients.

Funding

  • Government Support - Non-U.S.