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Abstract: PO2278

Urinary Sodium to Potassium Molar Ratio in Pediatric Stone Patients

Session Information

Category: Pediatric Nephrology

  • 1700 Pediatric Nephrology

Author

  • Master sankar raj, Vimal, University of Illinois College of Medicine at Peoria, Peoria, Illinois, United States
Background

The incidence of pediatric stone disease is on the rise. Dietary elements including high salt intake and reduced water consumption remain the major risk factors for stone formation. Urinary stone profile in pediatric literature remains limited. The purpose of the study is to get data on 24 hr urinary mineral excretion in pediatric stone formers with particular emphasis on these two research questions
1, How does urinary sodium/potassium (Na/K) molar ratio in pediatric stone patients compare to the national average intake data in USA?
2, How does risk factors of stone formation such as hypercalciuria correlates with dietary risk factors in pediatric stone formers?

Methods

This retrospective cohort study included all Pediatric stone patients who attended outpatient Nephrology clinic from 03/1/2014 to 10/1/2018. Children with known metabolic/genetic causes for stone disease, incomplete 24 hr urinary collection or on medications that affect mineral excretions were excluded from the study.

Results

150 patient charts were screened and 89 included in the study. Average age of the study population was 12.7 years with 58% females and 42% males. Mean Na/K molar ratio in pediatric stone patient was 3.7, statistically significantly higher than the national average of 2.5 using one sample T test (P < 0.001). Urinary calcium excretion showed a strong linear correlation with sodium excretion (r 0.545, P < 0.001). Multiple regression model using urinary calcium excretion as the dependent variable showed correlation with Urinary sodium excretion (P 0.004), urinary volume (P < 0.0001) and urinary Ph (P 0.001)

Conclusion

24 hr urinary sodium potassium molar ratio is significantly higher in stone formers indicating a higher salt and lower potassium consumption when compared to national average intake. Water intake, salt consumption and alteration of urinary Ph remains the main dietary modality to alter calcium excretion and hence reduce risk of stone formation