Abstract: PO0978
The Predictive Value of Diabetic Retinopathy on Subsequently Diabetic Nephropathy in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Prospective Studies
Session Information
- Diabetic Kidney Disease: Clinical - 1
October 22, 2020 | Location: On-Demand
Abstract Time: 10:00 AM - 12:00 PM
Category: Diabetic Kidney Disease
- 602 Diabetic Kidney Disease: Clinical
Authors
- Guan, Tianjun, Division of Nephrology, Zhongshan Hospital, Xiamen University,, Xiamen, China
- Li, Yu, Division of Nephrology, Zhongshan Hospital, Xiamen University,, Xiamen, China
- Chen, Anqun, Division of Nephrology, Zhongshan Hospital, Xiamen University,, Xiamen, China
Background
Studies have already demonstrated diabetic retinopathy (DR) was associated with an increased risk of diabetic nephropathy (DN) in patients with type 2 diabetes (T2D), whereas the predictive value of DR on subsequent DN for T2D were not illustrated. Therefore, we conducted a meta-analysis of prospective cohort studies to assess the predictive value DR on further DN risk in patients with T2D.
Methods
The PubMed, EmBase, and the Cochrane library were systematically searched for eligible prospective cohort studies through March 2020. The predictive value of NR were assessed using sensitivity, specificity, positive and negative likelihood ratio (PLR and NLR), diagnostic odds ratio (DOR), and area under the receiver operating characteristic curve (AUC).
Results
Ten prospective cohort studies recruited a total of 635 patients with T2D were selected for this study. After pooling all studies, we noted the pooled sensitivity, and specificity of DR for predicted DN were 0.64 (95%CI: 0.54-0.73), and 0.77 (95%CI: 0.60-0.88), respectively. The pooled PLR and NLR of DR for predicted DN were 2.72 (95%CI: 1.42-5.19), and 0.47 (95%CI: 0.33-0.67), respectively. The summary DOR for the relationship between DR and subsequent DN for T2D patients was 5.53 (95%CI: 2.00-15.30), and the AUC of DR for predicted DN was 0.73 (95%CI: 0.69-0.77). The predictive value of DR for subsequent DN could affect by mean age, percentage male, and study quality.
Conclusion
This study found significant associations between DR and subsequent DN risk for patients with T2D, while the predictive value of DR was mild. Further prospective study should be assessed for the predictive value of DR on other conditions in T2D patients with specific characteristics.
Funding
- Government Support - Non-U.S.