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Abstract: PO1240

Affecting Factors on Circuit Lifespan in Continuous Renal Replacement Therapy

Session Information

Category: Dialysis

  • 701 Dialysis: Hemodialysis and Frequent Dialysis

Authors

  • Shin, Hanwul, Wonju Severance Christian Hospital, Wonju, Gangwon-do, Korea (the Republic of)
  • Kim, Miryung, Wonju Severance Christian Hospital, Wonju, Gangwon-do, Korea (the Republic of)
  • Lee, Jun Young, Wonju Severance Christian Hospital, Wonju, Gangwon-do, Korea (the Republic of)
  • Yang, Jae Won, Wonju Severance Christian Hospital, Wonju, Gangwon-do, Korea (the Republic of)
  • Kim, Jae seok, Wonju Severance Christian Hospital, Wonju, Gangwon-do, Korea (the Republic of)
  • Choi, Seung-Ok, Wonju Severance Christian Hospital, Wonju, Gangwon-do, Korea (the Republic of)
  • Eom, Minseob, Wonju Severance Christian Hospital, Wonju, Gangwon-do, Korea (the Republic of)
Background

CRRT is a useful dialysis modality in hemodynamically unstable patients. But despite use of anticoagulants, clotting of circuit frequently occurs, which reduces efficiency of dialysis and causes the consumption of RBC, platelets, and coagulation factors. Especially, the more severe patient is, the lower blood flow into circuit due to hypotension can lead to decrease circuit lifespan. This study aims to investigate the factors that affects CRRT circuit lifespan.

Methods

This is a retrospective observational study. From January 2018 to December 2019, 38 patients who underwent CRRT in the ICU were enrolled. Outcomes were defined as the time of first clotting in circuit from CRRT initiation and the number of clotting during total application period. We statistically analyzed association of circuit lifespan with patient's clinical characteristics.

Results

The results showed that first circuit clotting was significantly related to serum bicarbonate (r=0.454, p=0.005) and creatinine levels (r=-0.359, p=0.026). The total number of circuit clotting were related to RBC and platelet transfusion respectively (r=0.779, p<0.001 / r=0.652, p<0.001). Blood pressure, infection, blood flow of circuit showed no relationships with circuit lifespan. The use of heparin and nafamostat increased circuit lifespan compared to non-anticoagulant.

Conclusion

Circuit lifespan in CRRT is shorter in more serious metabolic acidosis and renal failure. Transfusion of RBC and platelet also reduces the circuit lifespan.