Abstract: PO0455
The Phosphate-to-Urinary Urea Nitrogen Ratio (P/UUN): A Tool to Evaluate Phosphate Intake and Excretion in CKD Patients
Session Information
- CKD Risk Factors: Diet, Environment, Lifestyle
October 22, 2020 | Location: On-Demand
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2101 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention
Authors
- Pendon-Ruiz de Mier, Victoria, Instituto Maimonides de Investigacion Biomedica de Cordoba, Cordoba, Andalucía, Spain
- Rodelo-Haad, Cristian, Instituto Maimonides de Investigacion Biomedica de Cordoba, Cordoba, Andalucía, Spain
- Santamaria, Rafael, Instituto Maimonides de Investigacion Biomedica de Cordoba, Cordoba, Andalucía, Spain
- López baltanás, Rodrigo, Instituto Maimonides de Investigacion Biomedica de Cordoba, Cordoba, Andalucía, Spain
- Membrives González, Cristina, Instituto Maimonides de Investigacion Biomedica de Cordoba, Cordoba, Andalucía, Spain
- Munoz-Castaneda, Juan R., Instituto Maimonides de Investigacion Biomedica de Cordoba, Cordoba, Andalucía, Spain
- Martin-Malo, Alejandro, Instituto Maimonides de Investigacion Biomedica de Cordoba, Cordoba, Andalucía, Spain
- Soriano, Sagrario, Instituto Maimonides de Investigacion Biomedica de Cordoba, Cordoba, Andalucía, Spain
- Rodriguez Portillo, Mariano, Instituto Maimonides de Investigacion Biomedica de Cordoba, Cordoba, Andalucía, Spain
Background
Phosphate (P) restriction is crucial in CKD patients. Classically, P intake has failed to correlate with 24-h phosphaturia. Organic or inorganic P have different intestinal absorption rates, which might explain the lack of correlation between P intake and phosphaturia. Thus, we aimed to evaluate if the source of dietary P rather than the total P ingested determines phosphaturia, and to what extent inorganic P intake modifies phosphaturia
Methods
A 3-day dietary survey was performed in 71 stages G2-3 CKD patients to estimate the amount and source of P intake. 24-h urine samples were collected. Total phosphaturia, the FeP(%), and P/UUN, which reflect intestinal absorption of P relative to proteins absorbed and metabolized), were evaluated. P/UUN ratio tertiles were contrasted with the other variables analyzed (T1<58.9mg/g,T2=58.9-71.1mg/g,T3>71.1mg/g). Statistics were performed using Rv3.6.2
Results
The P intake was 1086.5±361.3 mg/day. P intake was 64.0%,22.1%, and 14.1% from animal, vegetables, and inorganic sources respectively. Total P intake did not correlate with urinary P (p=0.12), nor FeP. Patients ingesting more P ingested more inorganic P (Fig1). P intake correlated with P/UUN ratio(p=0.008). Patients in the upper P/UUN tertile showed the highest daily P intake (p=0.04) from inorganic sources (p=0.03), and the highest phosphaturia (p=0.04)
Conclusion
P/UUN reflects the total P intake and provides information about the amount of inorganic P, and could be used to guide the appropriate nutritional advice for CKD patients.
Fig1 Correlation between P intake and the different sources. A. Animal, B. Vegetal, C. Inorganic