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Kidney Week

Abstract: PO1298

Clinical Outcomes of Infection-Related Hospitalization in Incident Peritoneal Dialysis Patients

Session Information

Category: Dialysis

  • 703 Dialysis: Peritoneal Dialysis

Authors

  • Kim, Yong Kyun, Catholic University of Korea School of Medicine, Seoul, Seoul, Korea (the Republic of)
  • Kim, Jin, Ajou University School of Medicine and Graduate School of Medicine, Suwon, Gyeonggi-do, Korea (the Republic of)
Background

Infection is the second leading cause of death in patients undergoing long-term dialysis. Peritoneal dialysis (PD) is associated with an increased risk of infection-related hospitalization (IRH) when compared with hemodialysis. However, the effects of IRH on clinical outcomes in PD patients have not been established. In this study, we investigated the influence of IRH on clinical outcomes in incident PD patients.

Methods

In total, 583 incident PD patients were selected from the Clinical Research Center Registry for End-Stage Renal Disease, a nationwide multicenter prospective observational cohort study in Korea. Incident PD patients who had been hospitalized for infection-related diseases were categorized as the IRH group. The primary outcome was all-cause mortality and the secondary outcome was technical failure. The median follow-up period was 29 months.

Results

Seventy-three PD patients (13%) were categorized as the IRH group. Multivariate logistic regression analysis showed that diabetes mellitus was a significant independent predictor for IRH (odds ratio: 2.43, 95% confidence interval [CI]: 1.12–5.29, p=0.007). The most common causes of IRH were peritonitis (64.9%) and respiratory tract infection (11.9%). Multivariate Cox proportional hazard model analysis showed that IRH was a significant independent risk factor for all-cause mortality (hazard ratio [HR]: 2.51, 95% CI: 1.12–5.62, p=0.026) and for the technical failure of PD (HR: 3.23, 95% CI: 1.90–5.51, p<0.001).

Conclusion

Our data showed that after initiation of PD, IRH was significantly associated with higher risk of all-cause mortality and technical failure. Careful consideration of infection-related disease is needed in incident PD patients.