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Kidney Week

Abstract: PO0465

Relationship of Serum Triglycerides with Incident Albuminuria Among 114,817 US Veterans

Session Information

Category: CKD (Non-Dialysis)

  • 2101 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

  • Soohoo, Melissa, VA Long Beach Healthcare System, Long Beach, California, United States
  • Hsiung, Jui-Ting, VA Long Beach Healthcare System, Long Beach, California, United States
  • Marroquin, Maria V., VA Long Beach Healthcare System, Long Beach, California, United States
  • Kovesdy, Csaba P., Memphis VA Medical Center, Memphis, Tennessee, United States
  • Kalantar-Zadeh, Kamyar, Harold Simmons Center for Kidney Disease Research and Epidemiology, Orange, California, United States
  • Streja, Elani, VA Long Beach Healthcare System, Long Beach, California, United States
Background

The association of metabolic syndrome (MetS) components of impaired glucose, obesity, low high-density lipoprotein, hypertension, and serum triglycerides (TG), with renal endpoints such as incident chronic kidney disease (CKD) have been previously studied individually. Urine albumin to creatinine ratio (UACR) remains an integral part of CKD staging and incidence, yet it remains understudied. Thus, we sought to examine the relationship of TG with incident albuminuria among normal UACR patients with consideration for other MetS components.

Methods

Our cohort comprised 114,817 veterans with albuminuria stage A1 (<30 mg/g) and data on TG and MetS components. Incident albuminuria was defined as at least two UACR measurements of >30 mg/g at least 90 days apart. We used Cox proportional hazards models to evaluate the association of TG with incident albuminuria, adjusted for case-mix characteristics, laboratory values and individual MetS components, as well as stratified by ≤2 and ≥3 MetS components.

Results

The mean±SD age was 65±11, with a median[IQR] of TG, UACR and eGFR of 144[97, 214] mg/dL, 7[4, 13] mg/g, and 75[61, 89] mL/min/1.73m2 respectively, and 70% had at least 3 MetS components. We observed a linear association between TG and incident albuminuria after adjustment for case-mix and laboratory variables (ref: TG 120-<160 mg/dL). The association did not differ after adjustment for MetS components (Figure A). Moreover, stratification by number of MetS components showed similar linear associations between TG and incident albuminuria, especially in patients with ≥3 MetS components. In patients with ≤ 2 MetS components, the linear relationship of TG and incident albuminuria was attenuated (Figure B).

Conclusion

Higher TG are associated with incident albuminuria independent of other components of MetS. Further study is needed to understand the drivers of this association, with a specific focus of how to best manage TG levles in addressing albuminuria development.