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Kidney Week

Abstract: PO2181

Renal Recovery from AKI After Hematopoietic Stem Cell Transplant: A Systematic Review and Meta-Analysis

Session Information

  • Onco-Nephrology - 1
    October 22, 2020 | Location: On-Demand
    Abstract Time: 10:00 AM - 12:00 PM

Category: Onco-Nephrology

  • 1500 Onco-Nephrology

Authors

  • Kovvuru, Karthik, University of Mississippi Medical Center, Jackson, Mississippi, United States
  • Kanduri, Swetha Rani, University of Mississippi Medical Center, Jackson, Mississippi, United States
  • Cheungpasitporn, Wisit, University of Mississippi Medical Center, Jackson, Mississippi, United States
  • Thongprayoon, Charat, Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Medaura, Juan Antonio, University of Mississippi Medical Center, Jackson, Mississippi, United States
  • Kashani, Kianoush, Mayo Clinic Minnesota, Rochester, Minnesota, United States
Background

Patients with the recovery of renal function after an episode of acute kidney injury (AKI) have better outcomes compared to those without recovery. The current systematic review is conducted to assess the rates of kidney function recovery among patients with AKI or severe AKI requiring RRT within 100 days after hematopoietic stem cell transplant (HSCT).

Methods

Ovid MEDLINE, EMBASE, and the Cochrane Databases were systemically searched from database inceptions through August 2019 to identify studies reporting the rates of recovery from AKI after HSCT. Random-effects and generic inverse variance method of DerSimonian-Laird were used to combine the effect estimates obtained from individual studies.

Results

A total of 458 patients from 8 cohort studies with AKI after HSCT were enrolled. Overall, the pooled estimated rates of AKI recovery among patients with AKI and severe AKI requiring RRT within 100 days were 58% (95%CI: 37%-78%) and 10% (95%CI: 2%-4%), respectively. Among patients with AKI recovery, the pooled estimated rates of complete and partial AKI recovery were 60% (95%CI: 39%-78%) and 29% (95%CI: 10%-61%), respectively. There was no clear correlation between study year and the rate of AKI recovery (p =0.26).

Conclusion

The rate of recovery from AKI after HSCT depends on the severity of AKI. While recovery is common, complete recovery is reported in about two-thirds of all AKI patients. The rate of recovery among those with AKI requiring RRT is substantially lower.