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Abstract: PO0023

Decreased Urinary Uromodulin Is Potentially Associated with AKI: A Systemic Review and Meta-Analysis

Session Information

Category: Acute Kidney Injury

  • 101 AKI: Epidemiology, Risk Factors, and Prevention

Authors

  • Ruilian, You, Peking Union Medical College Hospital, Beijing, Beijing, China
  • Zheng, Hua, Peking Union Medical College Hospital, Beijing, Beijing, China
  • Chen, Limeng, Peking Union Medical College Hospital, Beijing, Beijing, China
Background

Conventional diagnostic criteria based on the serum creatinine isn't sensitive enough to detect Acute Kidney Injury (AKI) timely. Urinary uromodulin (uUMOD) is one of the novel biomarkers being studied for the value of predicting AKI. However, currently available publications showed inconsistent outcomes. This meta-analysis aimed to evaluate the potential association between uUMOD and AKI.

Methods

We searched research articles in Pubmed-Medline, Web of Science, Cochrane library, Embase, China National Knowledge Infrastructure, and Weipu Database(up to 2020.3). Random-effects models were used to estimate the standardized mean difference (SMD) between AKI and Non-AKI. The sensitivity analysis was conducted using the leave-one-out method. Random-effects meta-regression was performed to evaluate the impact of potential confounders on age and surgery.

Results

The meta-analysis was comprising 2678 subjects of 8 studies, which showed that the uUMOD in the patients with AKI was significantly lower than the Non-AKI patients (SMD:-0.77, P=0.001, 95% confidence interval -1.07,-0.47). Subgroup analysis indicated a significant difference in different ages and surgery group(Figure1-2). Sensitivity analysis displayed the synthetic outcome always in the 95% CI of the pool SMD suggesting a robust result.

Conclusion

The study suggests a potential negative association between uUMOD and AKI. Further studies are needed to investigate the promising diagnostic values and mechanisms in protecting AKI.