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Abstract: PO0708

Severe AKI in SARS-COVID-19 Patients from a Tertiary Hospital in Rhode Island

Session Information

Category: Coronavirus (COVID-19)

  • 000 Coronavirus (COVID-19)


  • Kota, Harshitha, Brown University, Providence, Rhode Island, United States
  • Mitchell, Kevin, Brown University, Providence, Rhode Island, United States
  • Tang, Jie, Brown University, Providence, Rhode Island, United States

The clinical features & outcomes of COVID-19 patients who developed severe AKI are still being elucidated.


42 patients with COVID-19 infection who developed KDOGI stage 3 AKI were identified from March 1 to May 15, 2020, at Rhode Island Hospital, a large tertiary teaching hospital. Their clinical presentations and outcomes are presented. The data in table 1 were presented as mean (± SD), median (IQR), or # (%).


The baseline characteristics are outlined in table 1. Among them, 88% were admitted to ICU, 83% were intubated and needed pressor support. 71% received renal replacement therapy (RRT)(56% on CVVHDF). The mean duration of RRT and ICU stay were 6 and 14 days, respectively. 33 participants received treatment for COVID-19, among them 14 (33%) received Remdesivir(RDV), 6 (14%) received convalescent plasma(CP), 4 (10%) received hydroxychloroquine(HCQ), and 25 (60%) also received azithromycin. The mortality rates were 15% in the RDV group, 67% in the CP group, and 75% in the HCQ group. The mortality was 67% in those without any treatment. At the 60-day follow-up, 11 (26%) were discharged alive, 21 (50%) died. Those who died were older (mean age 71 vs. 61), having higher Charlson Comorbidity Index (4.7 vs 3.0), more likely to have diabetes (71% vs. 61%) and coronary artery disease (38% vs. 24%).


The mortality rate of SARS-COVID patients who developed severe AKI is high in our cohort. Future larger scale studies are needed to elucidate the causes of this high mortality.

Table 1 Baseline and Presenting characteristics of the cohort
 Total Participants, n=42
Sex, Male33(79%)
Atrial fibrillation3(7%)
Baseline CKD20(48%)
Charlson Comorbidity Index3.7(±1.9)
Symptom, duration <1 week30(71%)


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