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Kidney Week

Abstract: PO0134

A Case of BK Polyomavirus-Associated Nephropathy of Native Kidneys in a 19-Year-Old Woman with a History of Orthotopic Cardiac Allotransplantation

Session Information

Category: Trainee Case Report

  • 102 AKI: Clinical, Outcomes, and Trials

Author

  • Wang, Ao, Loma Linda University Adventist Health Sciences Center, Loma Linda, California, United States

Group or Team Name

  • LLU nephrology
Introduction


BK polyoma virus associated nephropathy (BKPyVAN) is common among kidney transplant recipients. Approximately one to ten percent of kidney transplant recipients will develop BKPyVAN. BKPyVAN can lead to failure of the transplanted kidney allograft.

Case Description

A 20-year-old woman who had orthotopic cardiac allotransplantation in November of 2016 presented to the hospital in January of 2020 with upper respiratory tract infection like symptoms. Her baseline serum creatinine was 1.4 mg/dL three months prior to presentation. Her maintenance immunosuppression included tacrolimus and siroliumus. On admission her serum creatinine was 4.4 mg/dL. Nephrology was consulted and they recommended investigating for BK nephropathy. BK virus DNA quantification was positive for 352,364 BK virus copies/mL. On hospital day nine. The left native kidney biopsy revealed active BK-virus nephritis, patchy interstitial fibrosis and tubular atrophy.

Discussion

BK polyoma virus associated nephropathy of native kidneys is relatively rare. Upon our research we have only found a few case reports.