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Abstract: PO2247

The Spectrum of Biopsy-Proven Glomerular Diseases in Mexico: Experience at a Tertiary Hospital

Session Information

Category: Pathology and Lab Medicine

  • 1602 Pathology and Lab Medicine: Clinical

Authors

  • Garcia-Flores, Octavio Rene, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico, Estado de Mexico, Mexico
  • Martinez-Vazquez, Belen, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico, Estado de Mexico, Mexico
  • Soto, Virgilia, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico, Estado de Mexico, Mexico
  • Moguel, Bernardo, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico, Estado de Mexico, Mexico
Background

Glomerular diseases are still one of the leading causes of end-stage renal disease. The diagnosis of these diseases relies on the interpretation of the renal biopsy.

Methods

This investigation was performed in a tertiary hospital. We assessed the main demographic, clinical and histological data of individuals who underwent native kidney biopsies in one tertiary hospital in Mexico. From January 2011-December 2019, totally 1,541 patients first received renal biopsy. After excluding allograft biopsies, inadequate sampling, and failed interpretation, there are still 853 cases with a clear diagnosis.

Results

We evaluated 853 renal biopsies: female 65.3%, elderly (>60 years) 16.4%.
The most frequent biopsy-proven diseases were secondary (59.1%) and primary (28.7%) glomerulonephritis (GN), tubulointerstitial nephritis (TIN) was observed in 2.5 % and vascular diseases in 1.5%, hereditary disease in 1.2%. Among primary GN the most frequent diagnosis were focal segmental glomerulosclerosis (FSGS) (17.2%), membranous GN (MGN) (5.7%) and IgA nephropathy (IgAN) (4.8%). Among secondary GN, lupus nephritis (LN) represented 38.9%, diabetic nephropathy 8.1% and pauci-immune crecentic GN 4.9%.
The most common diseases in patients with nephrotic proteinuria were LN 14.8%, FSGS 5.8%, MGN 4.1%. Ultrasound needle guidance was used in 97.8%. The frequency of serious complications was approximately 2.5%.

Conclusion

This report provides representative population-based data on native biopsy-proven renal diseases in Mexico. FSGS and LN are the most frequent primary and secondary GN respectively. FSGS and MGN were the most common diseases in patients with nephrotic proteinuria.