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Kidney Week

Abstract: PO0703

Presentation on Admission and Outcomes in COVID Patients Admitted with AKI

Session Information

Category: Coronavirus (COVID-19)

  • No subcategory defined

Authors

  • Durrance, Richard Jesse, Icahn School of Medicine at Mount Sinai, Elmhurst Hospital, Elmhurst, New York, United States
  • Ram, Payal, Icahn School of Medicine at Mount Sinai, Elmhurst Hospital, Elmhurst, New York, United States
  • Catella, Paul, Icahn School of Medicine at Mount Sinai, Elmhurst Hospital, Elmhurst, New York, United States
  • Papademetriou, Demetrios, Elmhurst Hospital Center Department of Nephrology, Elmhurst, New York, United States
  • Coritsidis, George N., Icahn School of Medicine at Mount Sinai, Elmhurst Hospital, Elmhurst, New York, United States
Background

COVID-19 infection secondary to the SARS-CoV2 virus was defined by the WHO as a global pandemic. While the disease initially affects the respiratory system, a multi-systemic organ dysfunction of varying degrees has been described. Renal failure has been recognized as a significant part of the pathophysiology. Elmhurst Hospital Center (EHC) was described as the “epicenter of the epicenter” in New York City.

Methods

A retrospective chart review was undertaken of COVID positive adult patients (polymerase chain reaction testing of a nasopharyngeal sample) admitted to EHC from 3/7/20 - 4/7/20. Demographics, clinical characteristics, biomarkers, and outcomes were examined. AKI was determined by the KDIGO definition. Exclusion criteria: <18 years old, pregnant, ESRD, patients expired within first 5 days

Results

The average age was 59 years, 77.95% were Male; 55% had hypertension (HTN), 40% had diabetes (DM). Hispanics made up the most significant portion of the demographic with 62.05%, followed by Asians (24.1%). AKI occurred in 44.1% of patients and was associated with HTN ((p=0.011) but not DM (p=0.289). AKI was associated with an increased use of mechanical ventilation (p<0.001), and increased mortality (p<0.001). Hypertension (p=0.007), older age (p=0.003), and DM (p=0.018) were significantly associated with mortality. Ethinicity was not associated with mortality (p=0.231). Admission CPK did not have a significant association with AKI (0.065) or death (p=0.19).

Conclusion

Both HTN and DM are associated with increased mortality.
AKI is significantly associated with increased respiratory failure requiring mechanical ventilation and mortality.
Diabetes and admission CPK were not associated with AKI.

Demographics of patients admitted to EHC.
Demographicsn=195     
 MedianInterquartile range    
Age (years)5948 - 69    
  n%DeathP-value 
SexMale15277.95%690.339 
Female4322.05%16  
Past Medical HistoryHTNn=10754.87%560.007 
Diabetesn=7840%420.018 
ESRD on HDn=2010.26%70.413