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Abstract: INFO20

Kansas PKD Research and Translation Core Center

Session Information

Category: Genetic Diseases of the Kidneys

  • No subcategory defined

Authors

  • Calvet, James P., Jared Grantham Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas, United States
  • Wallace, Darren P., Jared Grantham Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas, United States
  • Tran, Pamela Vivian, Jared Grantham Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas, United States
  • Parnell, Stephen C., Jared Grantham Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas, United States
  • Mustafa, Reem, Jared Grantham Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas, United States
  • Yu, Alan S.L., Jared Grantham Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas, United States
Description

The Kansas PKD Research and Translation Core Center (RTCC) is comprised of an Administrative Core, three Biomedical Research Cores, Educational Enrichment Program, and Pilot Grant Program. In collaboration with the PKD Research Consortium, Central Coordinating Site and NIDDK, the Kansas PKD RTCC promotes PKD research by providing innovative and essential reagents, biomaterials, and services to the national PKD research community; the discovery of biomarkers and therapeutic targets; and the development of clinical trials to improve patient outcomes. The three Biomedical Research Cores are:

Biomarkers, Biomaterials and Cellular Models
Aim 1: Assist in ADPKD biomarker discovery and clinical sample analysis
Aim 2: Maintain a repository of high-quality human ADPKD biospecimens
Aim 3: Assist investigators in PKD cellular models and in vitro experimental analysis

Rodent Models and Drug Testing
Aim 1: Develop next-generation mouse models to study the genetics and function of cystogenic genes
Aim 2: Maintain a live-animal repository of rodent models and tissue for distribution
Aim 3: Provide drug testing and dietary intervention services in PKD rodent models
Aim 4: Provide longitudinal single-nucleus RNA-seq transcriptomics maps from Pkd1-mutant mice

Clinical Research
Aim 1: Develop a Central-Western ADPKD clinical trials network
Aim 2: Extend the early ADPKD observational cohort and biospecimen collection
Aim 3: Develop and disseminate a standardized data model for PKD trials
Aim 4: Build on our patient engagement resource to determine patient research priorities

The Kansas RTCC will enhance the PKD research environment with educational programs through a PKD Seminar Program, Summer Student Enrichment Program, PKD SuperGroup lab meetings, PKD Methods Workshop, Research Methods and Advanced Technologies Program, a Professional Development Seminar Series, patient-oriented activities, and through the consortium-wide PKD Annual Symposium. In collaboration with the PKD Research Consortium and with cooperating institutions nationwide, the Kansas PKD RTCC will
develop partnerships regionally and nationally to build teams to serve as a resource for the greater PKD research community by providing local and national infrastructure support, new research technologies, and increased numbers of patients involved in clinical trials.

Funding

  • NIDDK