Abstract: PO2430
Determinants of Serum β2 Microglobulin and β-Trace Protein in South Asians
Session Information
- CKD: Qualitative and Quantitative Observational Studies
November 04, 2021 | Location: On-Demand, Virtual Only
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2101 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention
Authors
- Wang, Yeli, Duke-NUS Medical School, Singapore, Singapore
- Levey, Andrew S., Tufts Medical Center, Boston, Massachusetts, United States
- Inker, Lesley Ann, Tufts Medical Center, Boston, Massachusetts, United States
- Jessani, Saleem, The Aga Khan University, Karachi, Sindh, Pakistan
- Bux, Rasool, The Aga Khan University, Karachi, Sindh, Pakistan
- Samad, Zainab Zs, The Aga Khan University, Karachi, Sindh, Pakistan
- Yaqub, Sonia, The Aga Khan University, Karachi, Sindh, Pakistan
- Karger, Amy B., University of Minnesota Medical School Twin Cities, Minneapolis, Minnesota, United States
- Allen, John C., Duke-NUS Medical School, Singapore, Singapore
- Jafar, Tazeen H., Duke-NUS Medical School, Singapore, Singapore
Background
β2-Microglobulin (B2M) and β-trace protein (BTP) are being considered for use with creatinine and cystatin C to improve the GFR estimation (Inker, AJKD 2020). In a Pakistani population, we showed that B2M and BTP did not improve the performance of eGFRcys and eGFRcr-cys (Wang, Kidney Week 2021). We aimed to evaluate non-GFR determinants of B2M and BTP in a general population in Pakistan.
Methods
We used linear regression models to assess associations between possible determinants and log-transformed levels of B2M and BTP adjusting for measured GFR among 557 participants (≥40 years) from Pakistan. The strength of significant associations was defined as strong, intermediate, or weak if the absolute percent difference in B2M or BTP levels was >10%, 5%-10% and <5%, respectively. R2 was calculated in a model including all determinants.
Results
Non-GFR determinants with intermediate and strong associations with higher BTP included male sex, history of heart disease, and lower waist circumference. Non-GFR determinants of higher B2M included male sex, higher total body fat, and lower serum albumin. As shown in Table below, the non-GFR determinants assessed in our study along with measured GFR could explain 64.2% and 78.2% variance of BTP and B2M, respectively.
Conclusion
Factors associated with non-GFR determinants of BTP and B2M differ from those of cystatin C and creatinine. These and unidentified factors limit their usefulness in improving eGFR among South Asians.
Table. Determinants and log-transformed filtration markers (N=557).
Funding
- NIDDK Support