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Kidney Week

Abstract: PO2430

Determinants of Serum β2 Microglobulin and β-Trace Protein in South Asians

Session Information

Category: CKD (Non-Dialysis)

  • 2101 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

  • Wang, Yeli, Duke-NUS Medical School, Singapore, Singapore
  • Levey, Andrew S., Tufts Medical Center, Boston, Massachusetts, United States
  • Inker, Lesley Ann, Tufts Medical Center, Boston, Massachusetts, United States
  • Jessani, Saleem, The Aga Khan University, Karachi, Sindh, Pakistan
  • Bux, Rasool, The Aga Khan University, Karachi, Sindh, Pakistan
  • Samad, Zainab Zs, The Aga Khan University, Karachi, Sindh, Pakistan
  • Yaqub, Sonia, The Aga Khan University, Karachi, Sindh, Pakistan
  • Karger, Amy B., University of Minnesota Medical School Twin Cities, Minneapolis, Minnesota, United States
  • Allen, John C., Duke-NUS Medical School, Singapore, Singapore
  • Jafar, Tazeen H., Duke-NUS Medical School, Singapore, Singapore
Background

β2-Microglobulin (B2M) and β-trace protein (BTP) are being considered for use with creatinine and cystatin C to improve the GFR estimation (Inker, AJKD 2020). In a Pakistani population, we showed that B2M and BTP did not improve the performance of eGFRcys and eGFRcr-cys (Wang, Kidney Week 2021). We aimed to evaluate non-GFR determinants of B2M and BTP in a general population in Pakistan.

Methods

We used linear regression models to assess associations between possible determinants and log-transformed levels of B2M and BTP adjusting for measured GFR among 557 participants (≥40 years) from Pakistan. The strength of significant associations was defined as strong, intermediate, or weak if the absolute percent difference in B2M or BTP levels was >10%, 5%-10% and <5%, respectively. R2 was calculated in a model including all determinants.

Results

Non-GFR determinants with intermediate and strong associations with higher BTP included male sex, history of heart disease, and lower waist circumference. Non-GFR determinants of higher B2M included male sex, higher total body fat, and lower serum albumin. As shown in Table below, the non-GFR determinants assessed in our study along with measured GFR could explain 64.2% and 78.2% variance of BTP and B2M, respectively.

Conclusion

Factors associated with non-GFR determinants of BTP and B2M differ from those of cystatin C and creatinine. These and unidentified factors limit their usefulness in improving eGFR among South Asians.

Table. Determinants and log-transformed filtration markers (N=557).

Funding

  • NIDDK Support