Abstract: PO2290
Renal Biopsy Is Mandatory in Normal Urinary Findings with Unknown Origin Hypertension or CKD
Session Information
- CKD: Drugs, Diet, and Other Determinants
November 04, 2021 | Location: On-Demand, Virtual Only
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2101 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention
Author
- Cho, Byoung-Soo, Dr.Cho's kidney Center, Deoul, Seoul, Korea (the Republic of)
Background
One of th most common causes of end stage renal disease are diabetes mellitus, hypertension and chronc glomerulonephritis, however most centers do not try to find the origin of hypertension especially in chronic kideny disease patients.
Most chronic glomerulonephritis patients usually associated with hematuria and or proteinuria. Most kidney centers do not recommend renal biopsy if proteinuria is absent even though associated with persistent hematuria.
In order to clarify the causes of hypertension or chronic kidney diseases, our center performed renal biopsy who showed unkown origin chronic kidney disease or unknown origin hypertension even though urinalysis findings showed no abnormalities.
Methods
From 2014 to 2020, we performed 1,300 cases of renal biopsy, of which 272 cases showed no urinary abnormalities when performing renal biopsy.
We perfomred renal biopsy not only in unknown origin hematuria and unknown origin proteinuria but also we perfomed renal biopsy in unkown origin CKD and unknown origin hypertension even though urinary findindings were normal at that time of renal biopsy.
Results
Of the 1,300 renal biopsy patients, 272(20.9%) showed normal urinalysis findings at that time of renal biopsy. Minor changes were detected in 2 cases among 272 cases. Most cases were serious chronic glomerulonephritis. Biopsy results were as follows: IgA nephrothy 98cases(36%), Mild focal nonspecific glomerulonephritis 43 cases(15.8%), Focal segmental glomerulosclerosis 39 cases(14.3%), Diffuse mesangial proliferative glomerulonephritis 39 cases(14.3%), Podocyte disease 8 cases (2.9%), Membranous nephropathy 6 cases((2.2%), C1q nephropathy 5 cases(1.8%), Lupus nephritis 4 cases(1.5%), malignant hypertension 3 cases1.1%), obesity related glomerulopathy 2 cases(0.7%), Minor change 2 cases(0.7%), C3GN 1 case(0.3%)
Conclusion
Most patients with CKD /hypertension patients without urinary abnormalities showed serious chronic glomerulonephrits such as IgA nephroapthy, FSGS, diffuse mesangial proliferative glomerulonephritis etc.
kidney biopsy is mandatory in unknown origin CKD /hypertension to clarify the original causes before considering antihypertensive medicine.