Kidney Week

Abstract: PO1254

Overweight and Obesity Predict Kidney Growth in Children and Young Adults with ADPKD

Session Information

• Cystic Kidney Disease - II
  November 04, 2021 | Location: On-Demand, Virtual Only
  Abstract Time: 10:00 AM - 12:00 PM

Category: Genetic Diseases of the Kidneys

• 1001 Genetic Diseases of the Kidneys: Cystic

Authors

• Steele, Cortney, University of Colorado - Anschutz Medical Campus, Aurora, Colorado, United States

Cortney Steele, PhD

• You, Zhiying, University of Colorado - Anschutz Medical Campus, Aurora, Colorado, United States

Zhiying You,

• Farmer-Bailey, Heather, University of Colorado - Anschutz Medical Campus, Aurora, Colorado, United States

Heather Farmer-Bailey,

• Gitomer, Berenice Y., University of Colorado - Anschutz Medical Campus, Aurora, Colorado, United States

Berenice Y. Gitomer,

• Chonchol, Michel, University of Colorado - Anschutz Medical Campus, Aurora, Colorado, United States

Michel Chonchol,

• Nowak, Kristen L., University of Colorado - Anschutz Medical Campus, Aurora, Colorado, United States

Kristen L. Nowak,

Background

We have previously reported that overweight and obesity are independently associated with more rapid progression in adults with early-stage autosomal dominant polycystic kidney disease (ADPKD). We now evaluated whether overweight and obesity are also associated with faster kidney growth in children and young adults with ADPKD.

Methods

54 non-diabetic children and young adults (6-25 years of age) with ADPKD and estimated glomerular filtration rate (eGFR) >80 ml/min/1.73m² who participated in a randomized controlled trial on curcumin supplementation were categorized based on BMI (if ≥18 years; n=27) or BMI percentile for age, sex, and height (if <18 years of age; n=27) as normal weight (n=40 [74%]) or overweight/obese (n=14 [26%]). The longitudinal (1-yr) association of overweight/obesity with change in height-corrected total kidney volume (htTKV) by magnetic resonance imaging was evaluated using multinomial logistic regression models.

Results

Mean+s.d. age was 18±5 years, annual % change in htTKV was 6.1±9.0%, and eGFR (full-age-spectrum equation) was 112±18 ml/min/1.73m². The annual % change htTKV was 5.5±9.1% in the normal weight participants and 7.9±8.6% in overweight/obese participants. After adjustment for demographics, randomization group, SBP, and glucose, overweight/obesity was associated with a nearly significant increased odds of annual % change htTKV ≥7% compared to <5% (Odds ratio: 5.23 [95% confidence interval: 0.99, 27.75]). This association was attenuated slightly after further adjustment for baseline htTKV and eGFR (5.58 [0.89, 34.96]).

Conclusion

Consistent with data in adults, our results suggest that overweight and obesity are associated with faster htTKV growth in children and young adults with ADPKD, although power is limited in this small sample size. These results highlight the importance of children with ADPKD maintaining a normal body mass index.

Funding

• NIDDK Support