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Kidney Week

Abstract: PO2278

Higher Frequency of Physical Activity Reduces the Risk of Kidney Function Loss in a General Non-Diabetic Population

Session Information

Category: CKD (Non-Dialysis)

  • 2101 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

  • Rismo, Renathe, Universitetssykehuset Nord-Norge, Tromso, Troms, Norway
  • Morseth, Bente, UiT Norges arktiske universitet, Tromso, Troms, Norway
  • Solbu, Marit D., Universitetssykehuset Nord-Norge, Tromso, Troms, Norway
  • Eriksen, Bjorn Odvar, Universitetssykehuset Nord-Norge, Tromso, Troms, Norway
  • Melsom, Toralf, Universitetssykehuset Nord-Norge, Tromso, Troms, Norway

Group or Team Name

  • Metabolic and Renal Research Group. UiT The Arctic University of Norway
Background

Physical activity (PA) reduces the risk of diabetes and hypertension, known risk factors for chronic kidney disease (CKD), but there is limited data on the independent association between PA and loss of kidney function. Previous population studies of PA have reported mixed results and relied on estimated glomerular filtration rate (eGFR). All eGFR equations are biased by non-GFR related factors such as muscle mass and inflammation, making confounding likely, particularly in studies of PA. We investigated the association between self-reported PA and the annual change of measured GFR in a general population cohort.

Methods

1627 subjects aged 50-62 years, without diabetes, cardiovascular disease or CKD were recruited from the general population in Tromsoe, Norway, and included in the Renal Iohexol Clearance Survey (RENIS) in 2007. Participants completed a questionnaire regarding frequency, intensity and duration of leisure-time PA, medication and comorbidities. GFR was measured using iohexol clearance at baseline and follow-up in 2013-15 and 2018-20. Linear mixed regression was used to analyze the association of PA with annual change in GFR, and logistic regression was used to assess the risk of accelerated GFR decline, defined as being those with the 10% steepest GFR decline.

Results

Mean (SD) age was 58 (3.8) years and 51% were female, median follow-up time was 11 years. Relative to participants that never exercise, the annual GFR decline rate for participants with PA once a week, 2-3 times a week or almost every day was slower by 0.40 (95% CI 0.05-0.76, p=0.026), 0.49 (95% CI 0.15-0.84, p=0.005) and 0.52 (95% CI 0.16-0.89, p=0.005) ml/min/1.73m2/year (linear trend p=0.002), in a fully adjusted model. Increasing frequency of PA was associated with a lower odds ratio (OR) of rapid kidney function decline, with an OR of 0.25 (95% CI 0.1-0.6, p=0.004) for the highest frequency of weekly PA compared to the group that never exercise, in a model adjusted for established risk factors for GFR decline (linear trend across groups p=0.011).

Conclusion

In this population-based study with repeated measurements of GFR during 11 years of follow-up, higher frequencies of leisure-time PA are associated with slower GFR decline.

Funding

  • Government Support – Non-U.S.