ASN's Mission

ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005


The Latest on Twitter

Kidney Week

Abstract: PO2365

Effects of Dapagliflozin in Patients with CKD and Albuminuria, with and Without Diabetes, by Use and Non-Use of Cardiovascular Medications: DAPA-CKD Trial

Session Information

Category: CKD (Non-Dialysis)

  • 2102 CKD (Non-Dialysis): Clinical, Outcomes, and Trials


  • Correa-Rotter, Ricardo, The National Medical Science and Nutrition Institute Salvador Zubiran, Mexico City, Mexico
  • Chertow, Glenn Matthew, Stanford University School of Medicine, Stanford, California, United States
  • Mark, Patrick B., University of Glasgow, Glasgow, Glasgow, United Kingdom
  • Nowicki, Michal P., Medical University of Lódz, Lódz, Poland
  • Vart, Priya, University Medical Center Groningen, Groningen, Netherlands
  • Jongs, Niels, University Medical Center Groningen, Groningen, Netherlands
  • Langkilde, Anna Maria, AstraZeneca, Gothenburg, Sweden
  • McMurray, John, University of Glasgow, Glasgow, Glasgow, United Kingdom
  • Rossing, Peter, Steno Diabetes Center Copenhagen, Gentofte, Denmark
  • Sjostrom, David, AstraZeneca, Gothenburg, Sweden
  • Stefansson, Bergur V., AstraZeneca, Gothenburg, Sweden
  • Toto, Robert D., UT Southwestern Medical Center, Dallas, Texas, United States
  • Wheeler, David C., University College London, London, London, United Kingdom
  • L Heerspink, Hiddo Jan, University Medical Center Groningen, Groningen, Netherlands

The DAPA-CKD trial (NCT03036150) demonstrated that dapagliflozin reduced the risk of kidney and cardiovascular (CV) events in patients with chronic kidney disease (CKD) and albuminuria with and without type 2 diabetes. We aimed to determine whether baseline CV medications modified dapagliflozin treatment effect.


We randomized 4304 adults with baseline eGFR 25–75 mL/min/1.73m2 and urinary albumin-to-creatinine ratio 200–5000 mg/g to either dapagliflozin 10 mg or placebo once daily. The primary endpoint was a composite of ≥50% estimated glomerular filtration rate (eGFR) decline, end-stage kidney disease, and kidney or CV death. Here we categorized patients according to baseline CV medication use.


Patients were required by protocol to receive a stable dose of a renin-angiotensin system inhibitor. The figure shows the effect of dapagliflozin compared with placebo, according to use of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers (97.0%), calcium channel blockers (50.7%), beta-blockers (39.0%), diuretics (43.7%), antithrombotic (47.4%) and lipid-lowering (69.4%) agents. The benefit of dapagliflozin was consistent across all background treatment subgroups, and findings were similar for pre-specified secondary outcomes (composite kidney endpoint, composite CV endpoint, and all-cause mortality).


The beneficial effects of dapagliflozin on kidney and CV endpoints in patients with CKD and albuminuria were evident among patients treated and not treated with a variety of CV medications.


  • Commercial Support