Abstract: PO0060
Outcomes of COVID-19 Infection in Dialysis vs. Kidney Transplant Patients: A Nationwide Cohort Study from Qatar
Session Information
- COVID-19: Epidemiology, Outcomes, Complications, and Risk Factors
November 04, 2021 | Location: On-Demand, Virtual Only
Abstract Time: 10:00 AM - 12:00 PM
Category: Coronavirus (COVID-19)
- 000 Coronavirus (COVID-19)
Authors
- Ghonimi, Tarek Abdellatif, Hamad Medical Corporation, Doha, Ad Dawhah, Qatar
- Hamad, Abdullah Ibrahim, Hamad Medical Corporation, Doha, Ad Dawhah, Qatar
- Alkadi, Mohamad M., Hamad Medical Corporation, Doha, Ad Dawhah, Qatar
- Abuhelaiqa, Essa, Hamad Medical Corporation, Doha, Ad Dawhah, Qatar
- Ibrahim, Rania Abdelaziz, Hamad Medical Corporation, Doha, Ad Dawhah, Qatar
- Kadukkamoottil, Shajahan Joseph, Hamad Medical Corporation, Doha, Ad Dawhah, Qatar
- Elgaali, Musab, Hamad Medical Corporation, Doha, Ad Dawhah, Qatar
- Othman, Muftah, Hamad Medical Corporation, Doha, Ad Dawhah, Qatar
- Ismail, Hany Ezzat, Hamad Medical Corporation, Doha, Ad Dawhah, Qatar
- Boubaker, Karima, Hamad Medical Corporation, Doha, Ad Dawhah, Qatar
- Al-Malki, Hassan A., Hamad Medical Corporation, Doha, Ad Dawhah, Qatar
Background
COVID-19 infection carries a high burden and poor outcomes in patients who are immunosuppressed like kidney transplant or on dialysis.
Our study aim is to compare outcomes between dialysis and kidney transplant patients infected with COVID-19 in the State of Qatar.
Methods
Retrospective cohort study reviewing medical, laboratory and radiographic data of all dialysis and kidney transplant recipients’ patients in our national registry (between February and August 2020). Data collected from a national-based electronic medical record.
Results
76 patients on dialysis patients had COVID19 vs 43 kidney transplants (p=ns). Kidney transplant patients with COVID19 tended to be younger than dialysis patients (52 vs. 58 years old, p=0.007), has less hypertension and more history of deep venous thrombosis. Clinical presentation did not differ between both groups with more asymptomatic in dialysis patients compared to kidney transplant patients (14.5% versus 2.3%, p=0.03). More patients died from COVID19 in the dialysis patients vs. kidney transplant patients (11 (14.5%) vs. only 1 (2.3%), p=0.034). Inflammatory markers were significantly higher in dialysis patients (IL6 peak and Ferritin) compared to kidney transplant patients.
Conclusion
Our national study showed similar incidence and severity of COVID19 in dialysis compared to kidney transplant in Qatar. Mortality and inflammatory markers were higher in dialysis patients.
| Dialysis N:76 | Transplant N:43 | p value | |
| Age | 58.7±14 | 52.0±10.4 | 0.007 |
| Sex: Male Female | 56 (73.6) 20 (26.3) | 34 (79.0) 9 (20.9) | 0.158 |
| Ethnic group: Middle east South Asia East Asia Others | 34 (44.7) 26 (34.2) 9 (11.8) 7 (9.2) | 27 (62.7) 16 (37.2)) 0 0 | 0.058 0.742 |
| Comorbidities: DM Hypertension IHD CHF Asthma H/O DVT Atrial Fibrillation | 48 (65.7) 75 (98.7) 19 (25) 2 (2.6) 7 (9.2) 4 (5.3) 8 (10.5) | 22 (51.1) 39 (90.6) 5 (11.6) 1 (2.3) 3 (6.9) 5 (11.6) 2 (4.6) | 0.663 0.03 0.524 0.823 0.515 0.010 0.212 |
| Vaccination: Flu vaccine | 52 (68.4%) | 30 (69.7) | 0.246 |
| SARS-Co2 symptoms at diagnosis: Fever Cough GIT symptoms Sore throat SOB Body pain Asymptomatic | 44 (57.9) 43 (56.6) 7 (9.2) 8 (10.5) 19 (25) 4 (5.3) 11 (14.5) | 18 (41.8) 21 (48.8) 6 (13.9) 4 (17.2) 6 (13.9) 8 (18.6) 1 (2.3) | 0.812 0.259 0.548 0.630 0.303 0.02 0.03 |
| Hypoxia | 18 (23.7) | 9 (20.9) | 0.730 |
| Chest x ray finding: Normal Unilateral Bilateral Not done | 21 (27.6) 10 (13.2) 45 (59.2) 0 | 14 (32.5) 7 (16.2) 16 (37.2) 6 (13.9) | 0.270 0.421 0.110 |
| Hospital stay (days) | 18.1±13.5 | 22.7±33.2 | 0.411 |
| ICU stay (days) | 18.1±13.5 | 22.7±33.2 | 0.411 |
| Outcome: Alive Dead ARDS ICU admission Mechanical Ventilation | 65 (85.5) 11 (14.5) 14 (18.4) 19 (25) 13 (17.1) | 42 (97.6) 1 (2.3) 5 (11.6) 9 (20.9) 5 (11.6) | 0.034 0.034 0.331 0.615 0.423 |
| Ferritin base | 1225.7±1478.2 | 393.2±526.4 | 0.001 |
| IL-6 peak | 717.3±2059.3 | 13.4±51.0 | 0.029 |