ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005

email@asn-online.org

202-640-4660

The Latest on X

Kidney Week

ASN / Education & Meetings / Kidney Week /

Please note that you are viewing an archived section from 2021 and some content may be unavailable. To unlock all content for 2021, please visit the archives.

Abstract: PO2288

Mortality Risk and Life-Years Associated with CKD for Young and Older Adults

Session Information

Category: CKD (Non-Dialysis)

  • 2101 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

  • Kula, Alexander J., Seattle Children's Hospital, Seattle, Washington, United States
  • Prince, David K., Kidney Research Institute, Seattle, Washington, United States
  • Katz, Ronit, University of Washington, Seattle, Washington, United States
  • Bansal, Nisha, Kidney Research Institute, Seattle, Washington, United States
Background

Younger individuals living with CKD face a lifetime at risk for complications, including an increased risk of mortality. There is limited data to inform individual patients with CKD across the lifespan how their risk for mortality compares with equivalently aged individuals without CKD. The objective of this study is to provide age specific contexts to the risk of mortality associated with a diagnosis of CKD.

Methods

We created a pooled study cohort using participants with CKD enrolled in the Chronic Renal Insufficiency Cohort along with participants aged 21-75 years with an eGFR >70mL/min/1.73m2 included in the 2002-2008 NHANES surveys. Age-stratified mortality rates, along with unadjusted and adjusted hazard ratios (HR) for mortality were generated to compare differences between those with and without CKD. Mean life-years-lost (LYL) relating to CKD were calculated using CDC life tables.

Results

A total of 17,550 participants (3,746 with CKD) were included. The adjusted HR for mortality relating to CKD was highest in the 21-35yr strata (HR [95% CI]: 5.6 [3.5, 9.0]) and lowest in the 65-75yr strata (HR [95% CI]: 1.9 [1.6, 2.1]). Mean LYL secondary to CKD was inversely related with increasing age (Fig. 1). An individual aged 21yrs old with CKD could expect a mean of 15.6 LYL compared to age-matched peers without CKD. A similar comparison in a 70-yr-old would translate to 2.9 LYL.

Conclusion

Compared to age-matched peers without CKD, the risk for mortality and LYL associated with a diagnosis of CKD is highest in younger individuals. Further research is needed to elucidate the societal and personal costs of premature mortality in young adults with CKD.

Funding

  • NIDDK Support