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Abstract: PO0058

Risk Factors for In-Hospital Mortality Among Patients Hospitalized with COVID-19 and ESKD

Session Information

Category: Coronavirus (COVID-19)

  • 000 Coronavirus (COVID-19)

Authors

  • Heilbronn, Jackson, Loma Linda University, Loma Linda, California, United States
  • Abdi Pour, Amir, Loma Linda University, Loma Linda, California, United States
  • Heidari-Bateni, Giv, Loma Linda University, Loma Linda, California, United States
  • Gharibvand, Lida, Loma Linda University, Loma Linda, California, United States
  • Agyeman, Kwame B., Loma Linda University, Loma Linda, California, United States
  • Grewal, Sahib Daljit Singh, Loma Linda University, Loma Linda, California, United States
  • Sharif, Mohammad, Loma Linda University, Loma Linda, California, United States
  • Infante, Sergio, Loma Linda University, Loma Linda, California, United States
  • Co, Mita Zahra Estrada, Loma Linda University, Loma Linda, California, United States
  • Norouzi, Sayna, Loma Linda University, Loma Linda, California, United States

Group or Team Name

  • Loma Linda Medical Center
Background

End Stage Kidney Disease (ESRD) has been shown to be a risk factor for poor outcomes in the setting of COVID-19 infection. Our study aims to identify risk factors for mortality in ESRD patients hospitalized with COVID-19.

Methods

We conducted a retrospective analysis from March 1st, 2020 to January 31st, 2021 at Loma Linda University Medical Center. Inclusion criteria included patients admitted with diagnosis of COVID-19 and history of ESRD prior to admission. Risk factors for hospital mortality were identified with univariate and multivariate logistic regression methods.

Results

A total of 92 patients (age 59.9±13.7) were included in the analysis of which 21(18.6%) were deceased. Univariate analysis (Figure 1) demonstrated that age odds ratio (OR) with 95% confidence interval (CI) for mortality 1.05 (95% CI: 1.01-1.09, P= 0.03), Positive D-dimer OR = 6.3 (95% CI: 1.29-27.9, P= 0.02), ejection fraction less than 50% OR=1.08 (95% CI: 2.62-28.77, P= <.0001), and ferritin >300 ng/ml OR=1.02 (95% CI: 1.01-1.03, P= 0.04) were associated with increased risk of hospital mortality. Adjusted multivariate analysis demonstrated that only ejection fraction less than 50% was associated with increased risk of mortality (OR 9.9, 95% CI: 2.2-45.1, P <.01)

Conclusion

Age, elevated D-dimer, elevated ferritin and heart failure with reduced ejection fraction were identified as risk factors for hospital mortality of ESRD patients with COVID-19 infection.