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Kidney Week

Abstract: INFO26

Mayo Clinic Polycystic Kidney Disease Center (MCPC)

Session Information

  • Informational Posters
    November 04, 2021 | Location: On-Demand, Virtual Only
    Abstract Time: 10:00 AM - 12:00 PM

Category: Genetic Diseases of the Kidneys

  • No subcategory defined

Authors

  • Senum, Sarah R., Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Thao, Ka, Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Gregory, Adriana, Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Li, Xiaoyan, Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Olinger, Leif G., Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Mann, Zoey, Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Sieben, Cynthia J., Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Romero, Michael F., Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Sussman, Caroline R., Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Chebib, Fouad T., Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Irazabal, Maria V., Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Li, Xiaogang, Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Hu, Jinghua, Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Kline, Timothy L., Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Torres, Vicente E., Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Harris, Peter C., Mayo Clinic Minnesota, Rochester, Minnesota, United States
Description

The Mayo Clinic PKD Center (MCPC) leverages expertise spanning basic research through clinical trials and practice to provide core services, reagents, and insights that support academic and industry-sponsored PKD research. These services are designed to promote basic research breakthroughs and facilitate their translation into improvements in clinical practice. The Center consists of three Cores: 1) Genetics, Epigenetics and Metabolomics (GEM), 2) Model Systems, and 3) Imaging. The GEM Core utilizes state of the art approaches to genetically characterize human PKD populations, enable biomarker discovery, and facilitate clinical trials. The GEM contains the Cystic Kidney and Liver Disease Biobank that collects, shares, and utilizes PKD patient materials to catalyze the understanding of disease pathogenesis. The Model Systems Core empowers PKD research through developing and facilitating access to PKD models in C. elegans, zebrafish, rodents, and pigs. Studies of new and established models provide insights into disease mechanisms and biomarkers for tracking disease initiation and progression. A standardized protocol for murine preclinical testing is available for testing novel therapeutics, and C. elegans and zebrafish models provide higher throughput/lower cost drug screening platforms. The Imaging Core develops standardized protocols for both preclinical and clinical imaging using ultrasound, CT, and MRI. The core also provides accurate and automated analysis of imaging data including organ volume, cyst number and size distributions, and body composition analysis and has developed and utilized novel image acquisition techniques (3D ultrasound, quantitative MRI) and image processing techniques (radiomics, machine learning, and deep learning analysis) to provide enhanced patient-specific image-based metrics. The PKD Foundation ADPKD Mutation Database collates and evaluates the significance of variants in the PKD1 and PKD2 genes to aid diagnostics and categorization of patient populations. Summer Undergraduate Research Fellowships are available through an R25 grant for training in PKD within the MCPC.