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ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

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Kidney Week

Abstract: INFO10

NUGoKidney Research Cores: Paving the Way for Breakthroughs in Kidney Therapeutics

Session Information

  • Informational Posters
    November 04, 2021 | Location: On-Demand, Virtual Only
    Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

  • No subcategory defined

Authors

  • Sipocz, Ashley, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
  • Kapitsinou, Pinelopi P., Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
  • Isakova, Tamara, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
  • Quaggin, Susan E., Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States

Group or Team Name

  • NUGoKidney Executive Board
Description

Funded by the National Institute of Diabetes and Digestive and Kidney Diseases, the Northwestern University George M. O’Brien Kidney Research Core Center (NUGoKIDNEY) supports innovative research and cross-cutting collaborations to advance the discovery of novel therapeutics to transform the prevention and treatment of kidney diseases. The Center unites investigators across three cores covering all aspects of the kidney therapeutic pipeline from basic discovery-based (Pre-Clinical Models Core [A]) to design and development of nephrotherapeutics including biologics, nanoparticles and cell-based reagents (Therapeutics Design and Development Core [B]) to design and execution of clinical trials (Clinical and Translational Core [C]). Core A offers researchers access to over 30 unique kidney disease models and cell-specific knockout lines, concierge genome editing services, and services enabling generation of induced pluripotent stem cells from patients with kidney diseases. Core B brings together the expertise and cutting-edge techniques of Northwestern’s research infrastructure to support development of bio-inspired nano-delivery systems, biological and small molecule therapeutics, and cell-based therapeutics for precision targeting kidney disease-specific pathogenesis. Core C connects investigators with clinical research services, including clinical research coordinator support; analytic, clinical trial, patient-reported outcomes, and bioethics expertise; unique data and biosample repositories; and input from community-engaged researchers.
NUGoKIDNEY's Pilot and Feasibility Program offers pilot grants to support cross-disciplinary translational research for the identification and development of new therapies for kidney disease. The Enrichment Program provides education and outreach activities that (1) provide training and career development for next-generation researchers and (2) share new knowledge with the scientific and lay communities. Notable activities include hosting an annual Kidney Disease Therapeutic Innovation Symposium; community-engaged partnership development to improve kidney health disparities on Chicago’s South Side; and a vibrant high school program – SciHigh – that prepares students from underrepresented backgrounds for biomedical careers through summer mentorship, workshops, and classroom activities.

Funding

  • The core services and resources of Northwestern's George M. O'Brien Kidney Research Core Center presented in this abstract are supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) ​(P30 DK114857).