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Kidney Week

Abstract: TH-PO1038

Racial/Ethnic Differences in Socioeconomic Status (SES) and Health-Related Quality of Life (HRQL) Among Children with Glomerular Disease in Cure Glomerulonephropathy (CureGN)

Session Information

Category: Glomerular Diseases

  • 1203 Glomerular Diseases: Clinical, Outcomes, and Trials


  • Krissberg, Jill, Stanford Health Care, Redwood City, California, United States
  • Helmuth, Margaret, Arbor Research Collaborative for Health, Ann Arbor, Michigan, United States
  • Aviles, Diego H., LSUHSC, New Orleans, Louisiana, United States
  • Cai, Yi, Helen DeVos Children's Hospital, Grand Rapids, Michigan, United States
  • Gbadegesin, Rasheed A., Duke University Medical Center, Durham, North Carolina, United States
  • Gibson, Keisha L., University of North Carolina Kidney Center, Chapel Hill, North Carolina, United States
  • Greenbaum, Larry A., Emory University, Atlanta, Georgia, United States
  • Hidalgo, Guillermo, Eastern Carolina University, Greenville, North Carolina, United States
  • Hingorani, Sangeeta R., Seattle Children’s Hospital, Seattle, Washington, United States
  • Iragorri, Sandra, University of Oregon, Portland, Oregon, United States
  • Khalid, Myda, Indiana University, Indianapolis, Indiana, United States
  • Lafayette, Richard A., Stanford University, Stanford, California, United States
  • Mason, Sherene, Connecticut Children's Medical Center, New Haven, Connecticut, United States
  • Parekh, Rulan S., The Hospital For Sick Children, Toronto, Ontario, Canada
  • Selewski, David T., Medical University of South Carolina, Charleston, South Carolina, United States
  • Trachtman, Howard, NYU Langone Health, New York, New York, United States
  • Tuttle, Katherine R., University of Washington School of Medicine, Spokane, Washington, United States
  • Twombley, Katherine, Medical University of South Carolina, Charleston, South Carolina, United States
  • Vasylyeva, Tetyana L., Texas Tech Health Sciences Center, Lubbock, Texas, United States
  • Wenderfer, Scott E., Baylor College of Medicine, Houston, Texas, United States
  • O'Shaughnessy, Michelle M., Stanford University, Stanford, California, United States

Race/ethnicity, disease severity/duration, and lower SES have been associated with poorer HRQL in children with glomerular disease; however, the relative importance of these factors has not adequately been explored.


CureGN is a 70-center cohort study of patients with MCD, FSGS, MN, or IgAN/IgAV. We compared pediatric patient characteristics (demographics, disease duration/severity, medications, SES) at enrolment across racial/ethnic groups. Multivariable logistic and linear regression models, created using best subsets and backwards selection, were used to examine associations between race/ethnicity and HRQL, as measured by missed school days due to kidney disease and baseline PROMIS questionnaire items.


Among 515 White, 146 Black and 74 Hispanic children, Blacks were most likely to have FSGS/MCD and had the lowest eGFR, highest urine protein, lowest serum albumin, and most severe edema. Compared to Whites, Blacks or Hispanics were less likely to have private insurance (59, 35, and 32%, p<0.001), and their parents/guardians were less likely to have completed college (18, 7, and 10% of mothers, and 30, 12, and 12% of fathers, p<0.001). Racial/ethnic differences in HRQL were small (below the Minimally Important Difference of 3) and generally not statistically significant (table). No differences in missed school days due to kidney disease were observed.


Among pediatric CureGN patients, SES varied by minority status such that Black or Hispanic (vs. White) children were less likely to have private insurance and their parents received less formal education. After adjusting for SES and other factors, minority status was not associated with HRQL as measured within this study.


  • NIDDK Support