Abstract: SA-PO827
Obestatin Response to a Meal and Association with Subsequent Appetite Sensations in Maintenance Hemodialysis Patients
Session Information
- Health Maintenance, Nutrition, Metabolism - II
November 09, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Health Maintenance, Nutrition, and Metabolism
- 1300 Health Maintenance, Nutrition, and Metabolism
Authors
- Beberashvili, Ilia, Assaf Harofeh Medical Center, Zerifin, Israel
- Azar, Ada, Assaf harofeh medical center, Zerifin, Israel
- Abu hamad, Ramzia, Assaf Harofeh Medical Center, Zerifin, Israel
- Efrati, Shai, Assaf Harofeh Medical Center, Zerifin, Israel
Background
Obestatin, a physiological opponent of acylated ghrelin, linked to the regulation of appetite reducing food intake in mice but its anorexigenic property in human is controversial. We aimed to investigate a potential role of obestatin in dietary intake regulation by examining response to a meal in maintenance hemodialysis (MHD) patients.
Methods
In this case-control study we have investigated the response of obestatin around a fixed calorie meal (500 kcal) in 21 MHD patients (age 69.2±13.1 years, 10 women, with body mass index 27.2±5.5 kg/m2). Parallel changes in serum obestatin and insulin levels and subjective scores of appetite (visual analogue scales for hunger, satiety, fullness and prospective food consumption) were recorded on fasting and 30, 60 and 120 min after meal.
Results
In a linear mixed effects model controlling for baseline demographics and clinical parameters including serum insulin concentrations, postprandial levels of obestatin did not change significantly from baseline in response to the meal. The response was the same in MHD patients treated with high or low flux dialyzers. However, postprandial obestatin levels were associated with the rate of change in sensation of fullness (linear estimate: 11.60 (95% confidence interval 0.17 to 23.04, P<0.05). The remained sensations of appetite did not correlate with postprandial obestatin levels in time.
Conclusion
Obestatin levels do not change acutely with food administration in MHD patients, but associate with the changes in sensation of fullness. This supports the possible role of obestatin in the long-term regulation of appetite in MHD population.