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Abstract: FR-PO459

Predilution Online Hemodiafiltration Improves Health-Related Quality of Life (HRQoL) in Patients Undergoing Hemodialysis

Session Information

Category: Dialysis

  • 701 Dialysis: Hemodialysis and Frequent Dialysis


  • Kuragano, Takahiro, Internal Medicine Division of Kidney and Dialysis, Nishinomiya, Japan

Sarcopenia and frailty condition cause aggravation of the health-related quality of life (HRQoL) including physical, psychological, and social aspects. Furthermore, these conditions are associated with a high risk of hospitalization and mortality of mantenance hemodialysis (MHD) patients. The effect of OL-HDF on the HRQoL has not been established. In this study, we compared the effect of nutritional conditions and HRQoL between patients treated by OL-HDF and conventional HD using a superflux dialyzer.


Thirty-eight MHD patients were enrolled in this crossover study. All patients were treated with conventional HD using a superflux dialyzer for first the 4 months (1st CHD period), were switched to predilution OL-HDF for 4 months (OL-HDF period) and then were returned to conventional HD using the superflux dialyzer for the next 4 months (2nd CHD period). We evaluated clinical parameters, the fat mass and muscle mass, and HRQoL using the KDQOL-SF™


No significant difference in serum albumin in the patients with a higher serum albumin level was observed. However, in patients with low albumin, the levels significantly increased (3.6±0.1 to 3.8±0.1 g/dL) during the OL-HDF period. Moreover, although there was no significant difference in the patients with a higher fat mass, fat mass significantly increased (8.0±2.1 to 8.6±2.4 kg) in patients with a lower fat mass during the OL-HDF period. Increased serum albumin and fat mass values during the OL-HDF period returned to baseline levels during the 2nd CHD period. No significant difference in the mental health and body pain score was found during the study period. Although there was no significant difference in the patients with a higher score of physical functioning (PF), role physical (RP), vitality (VT), and social functioning (SF), the patients with a lower score during the 1st CHD period showed significantly increased in these scores (PF: 28.3 ±11.7 to 30.3±11.5, RP: 33.5±9.5 to 37.9, VT: 41.4±5.6 to 43.8±7.4, and SF: 32.4±7.5 to 36.7±8.3, respectively) during the OL-HDF period. These scores decreased to base line levels during the 2nd CHD period.


In this crossover study, we revealed that compared with conventional HD using a superflux dialyzer, OL-HDF significantly improved the nutritional conditions and score of HRQoL in MHD patients with sarcopenia.