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Abstract: FR-PO226

Acute Changes in Estimated Glomerular Filtration Rate and Related Factors and Subsequent Renal Function in Type 2 Diabetes Mellitus After Initiating Luseogliflozin

Session Information

Category: Diabetic Kidney Disease

  • 602 Diabetic Kidney Disease: Clinical

Authors

  • Kohagura, Kentaro, University of the Ryukyus Hospital, Nishihara-cho, Okinawa, Japan
  • Ohya, Yusuke, University of the Ryukyus, Nishihara-cho, OKINAWA, Japan
Background

Acute fall in estimated glomerular filtration rate (eGFR), typical finding after initiating sodium glucose transporter 2 (SGLT2) inhibitors link to maintaining renal function among patients with diabetes mellitus. However, the relationship between magnitude of acute fall in eGFR and course of eGFR thereafter are not known.

Methods

A pooled analysis of four 52-week Phase III trials of luseogliflozin 2.5 mg daily (or up to 5 mg daily) in Japanese patients (N=941) with type 2 diabetes mellitus stratified according to the tertile of magnitude of acute changes in eGFR during 2 weeks after initiating it was conducted.

Results

The mean for age, HbA1c, estimated glomerular filtration rate, and urinary albumin were as follows: 60 years, 7.8%, and 79.6 ml/min/1.73m<span style="font-size:10.8333px">2</span>, 62.7 mg/gCr respectively. Acute changes in eGFR were widely varied among the patients with type 2 diabetes mellitus (mean,-2.3; min, -35.5; max, 27.6). Course of eGFR after 2 weeks of initiating luseogliflozin were rather recovered or maintained regardless of acute changes in eGFR. The patients with greater acute decline in eGFR, who were characterized by higher eGFR and body mass index, higher prevalence of using diuretics and lower uric acid, showed rapid recovery and maintenance of eGFR thereafter. Multivariate regression analysis revealed that higher body mass index, higher eGFR and use of diuretics were associated with greater acute decline in eGFR.

Conclusion

Although acute changes in eGFR widely varied among the type 2 diabetes mellitus with preserved renal function, the course of eGFR thereafter was maintained regardless of the degree of acute changes in eGFR. State of basal glomerular filtration rate and interaction of diuretics may relate to acute changes in eGFR after initiating SGLT2 inhibitor.

Funding

  • Commercial Support