ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005

email@asn-online.org

202-640-4660

The Latest on X

Kidney Week

Please note that you are viewing an archived section from 2019 and some content may be unavailable. To unlock all content for 2019, please visit the archives.

Abstract: TH-PO218

True Arterial Stiffness Does Not Change Between Dialysis Sessions During 1 Week in Outpatients on Intermitted Hemodialysis

Session Information

Category: Dialysis

  • 701 Dialysis: Hemodialysis and Frequent Dialysis

Authors

  • Reshetnik, Alexander, Charité – Universitätsmedizin Berlin, a corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
  • Wrobel, Daniel, DIAVITAL, Kamen, Germany
  • Wirtz, Georg, Dialysezentrum Kamen, Kamen, Germany
  • Eckardt, Kai-Uwe, Charité – Universitätsmedizin Berlin, a corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
  • van der Giet, Markus, Charité – Universitätsmedizin Berlin, a corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
Background

End-stage renal disease (ESRD) is associated with exponentially elevated cardiovascular mortality. Higher pulse wave velocity (PWV) values are frequently observed in patients with ESRD. However, the intrinsic physiologic relationship between PWV and prevailing arterial pressure can deteriorate its cardiovascular predictive value making an individual pressure-independent expression of PWV essential.

Methods

Dialysis patients from a single outpatient unit obtained repeated measurements of blood pressure (BP) and pulse wave analysis during each dialysis session of one week. Aortic PWV was then adjusted to 120 mmHg central systolic BP based on individually determined relationship.

Results

54 subjects were included. The median age was 75.5 years. Mean systolic/diastolic BP was 121.4/70.5 mmHg and the median heart rate was 64.6 beats/min. Mean PWV was 10.9 m/s and mean PWV120 was 11.3 m/s. PWV120 did not change across single dialysis session during one week, while systolic, diastolic BP, PWV and ultrafiltration volume differed significantly.

Conclusion

Our data suggest that true AS does not change in the short-term course in dialysis patients and observed changes in PWV are rather associated with BP change due to intrinsic pressure-dependence. Our analytical approach represents a novel method for this purpose, which is easy in performance and also applicable for large interventional trials and clinical practice.

Change in A- systolic, diastolic, central systolic blood pressure (BP) and B- pulse wave velocity (PWV) and PWV adjusted to 120 mmHg central systolic blood pressure (PWV120) between the dialysis days of one week