Abstract: TH-PO218
True Arterial Stiffness Does Not Change Between Dialysis Sessions During 1 Week in Outpatients on Intermitted Hemodialysis
Session Information
- Hemodialysis and Frequent Dialysis - I
November 07, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 701 Dialysis: Hemodialysis and Frequent Dialysis
Authors
- Reshetnik, Alexander, Charité – Universitätsmedizin Berlin, a corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
- Wrobel, Daniel, DIAVITAL, Kamen, Germany
- Wirtz, Georg, Dialysezentrum Kamen, Kamen, Germany
- Eckardt, Kai-Uwe, Charité – Universitätsmedizin Berlin, a corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
- van der Giet, Markus, Charité – Universitätsmedizin Berlin, a corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
Background
End-stage renal disease (ESRD) is associated with exponentially elevated cardiovascular mortality. Higher pulse wave velocity (PWV) values are frequently observed in patients with ESRD. However, the intrinsic physiologic relationship between PWV and prevailing arterial pressure can deteriorate its cardiovascular predictive value making an individual pressure-independent expression of PWV essential.
Methods
Dialysis patients from a single outpatient unit obtained repeated measurements of blood pressure (BP) and pulse wave analysis during each dialysis session of one week. Aortic PWV was then adjusted to 120 mmHg central systolic BP based on individually determined relationship.
Results
54 subjects were included. The median age was 75.5 years. Mean systolic/diastolic BP was 121.4/70.5 mmHg and the median heart rate was 64.6 beats/min. Mean PWV was 10.9 m/s and mean PWV120 was 11.3 m/s. PWV120 did not change across single dialysis session during one week, while systolic, diastolic BP, PWV and ultrafiltration volume differed significantly.
Conclusion
Our data suggest that true AS does not change in the short-term course in dialysis patients and observed changes in PWV are rather associated with BP change due to intrinsic pressure-dependence. Our analytical approach represents a novel method for this purpose, which is easy in performance and also applicable for large interventional trials and clinical practice.
Change in A- systolic, diastolic, central systolic blood pressure (BP) and B- pulse wave velocity (PWV) and PWV adjusted to 120 mmHg central systolic blood pressure (PWV120) between the dialysis days of one week