Abstract: TH-PO214
Comparison of Pressure-Independent Pulse Wave Velocity Between Haemodialysis Patients and Patients with Preserved Kidney Function
Session Information
- Hemodialysis and Frequent Dialysis - I
November 07, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 701 Dialysis: Hemodialysis and Frequent Dialysis
Authors
- Reshetnik, Alexander, Charité – Universitätsmedizin Berlin, Berlin, Germany
- Wrobel, Daniel, DIAVITAL, Kamen, Germany
- Wirtz, Georg, Dialysezentrum Kamen, Kamen, Germany
- Eckardt, Kai-Uwe, Charité – Universitätsmedizin Berlin, Berlin, Germany
- van der Giet, Markus, Charité – Universitätsmedizin Berlin, Berlin, Germany
Background
Chronic kidney disease (CKD) is associated with progressive arteriosclerosis and increased arterial stiffness (AS) – expressed as higher measured aortic pulse wave velocity (aPWV) – has been frequently described in dialysis patients. However, the intrinsic physiologic relationship between aPWV and prevailing arterial pressure complicates the direct comparison of aPWV values between different collectives. An individual pressure-independent expression of aPWV could be a possible solution.
Methods
Hemodialysis patients were age- and sex-matched with patients with preserved kidney function. Long-term measurements (24 hours for patients with preserved kidney function and 44 hours for haemodialysis patients) of blood pressure (BP) and aPWV were obtained . aPWV was then adjusted to 120 mmHg central systolic BP (PWV120) based on individually determined relationship and mean PWV120 was compared between the two collectives.
Results
45 patients were included in each group. Haemodialysis group had significantly higher prevalence of diabetes mellitus and significantly more patients with hyperlipoproteinemia, history of coronary heart disease, stroke and peripheral artery disease, while patients with preserved renal function had significantly higher systolic and diastolic BP. PWV120 did not differ between the groups.
Conclusion
In our study, we used BP-adjustment for pressure-independent expression of aPWV. Our results show that pressure-independent aPWV did not differ between patients on haemodialysis and with preserved kidney function. This finding is in contrast to previous reports and prompts questions about association between AS and CKD. However, more data are needed to reproduce the results for further assessment.
Haemodynamic parameters
| systolic blood pressure, mmHg | 119.4±13.6 | 134.9±16.2 |
| diastolic blood pressure, mmHg | 67.8±10.5 | 78.3±8.6 |
| heart rate, beats/min | 68.3±9.3 | 69.7±10.0 |
| central systolic blood pressure, mmHg | 106.6±13.1 | 122.3±14.0 |
| aortic Pulse wave velocity, m/s | 11.0 [9.2-12.8] | 10.9 [9.1-12.8] |
| PWV120, m/s | 10.9±2.5 | 10.8±2.5 |