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Abstract: TH-PO701

Predictive Value of Cardio Ankle Vascular Index on the Risk of ESRD

Session Information

Category: Hypertension and CVD

  • 1401 Hypertension and CVD: Epidemiology, Risk Factors, and Prevention

Authors

  • Jeong, Jinseon, Seoul National University Hospital, Seoul, Korea (the Republic of)
  • Kim, Dong Ki, Seoul National University Hospital, Seoul, Korea (the Republic of)
  • Han, Seung Seok, Seoul National University College of Medicine, Seoul, Korea (the Republic of)
Background

Arterial stiffness is a great concern in relation to high mortality and cardiovascular event. However, the predictive value of pulse wave velocity, one of assessment tools for arterial stiffness, on the risk of end-stage renal disease (ESRD) remains unresolved.

Methods

A total of 9,005 patients who measured cardio-ankle vascular index (CAVI) were included in the study. Patients were divided according to the value (9.0) of CAVI or the quartiles of CAVI. The hazard ratios (HRs) of ESRD and all-cause mortality were calculated using the multivariable-adjusted Cox model. We also analyzed the competing risk regression to adjust the death.

Results

During the median follow-up period of 7 years (maximum 12 years), the events of ESRD and mortality occurred in 215 and 1,079 patients, respectively. The median value of CAVI was 8.5. The high CAVI group (> 9.0) had a higher risk of ESRD than the low CAVI group (HR, 1.65 [1.27–2.16]; P < 0.001). The risk of all-cause mortality was also higher in the high CAVI group than in the low CAVI group (HR 2.84 [2.51–3.21]; P < 0.001). Although the analysis was performed based on the quartiles, the 4th quartile group had a higher risk of ESRD (HR, 2.20 [1.48–3.27]; P < 0.001) than the 1st quartile group. The risk of all-cause mortality was also higher in the 4th quartile than in the 1st quartile (HR, 4.21 [3.46–5.12]; P < 0.001). The death-adjusted risk analysis also showed that the 4th quartile group had a high risk of ESRD than the 1st quartile (HR, 2.21 [1.49–3.28]; P < 0.001).

Conclusion

The measurement of CAVI by the pulse wave velocity may be needed to predict the risk of ESRD.