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Kidney Week

Abstract: TH-PO717

Sex Disparities and Risk of CKD: A Nationwide Cohort Study of 10.8 Million Adults in Korea

Session Information

Category: Women’s Health and Kidney Diseases

  • 2000 Women’s Health and Kidney Diseases

Authors

  • Kang, Shinchan, College of Medicine, Institute of Kidney Disease Research, Yonsei University, Seoul, Korea (the Republic of)
  • Jung, Chan-Young, College of Medicine, Institute of Kidney Disease Research, Yonsei University, Seoul, Korea (the Republic of)
  • Ko, Byounghwi, College of Medicine, Institute of Kidney Disease Research, Yonsei University, Seoul, Korea (the Republic of)
  • Jo, Wonji, College of Medicine, Institute of Kidney Disease Research, Yonsei University, Seoul, Korea (the Republic of)
  • Chang, Tae ik, National Health Insurance Service Medical Center, Ilsan Hospital, Gyunggi-do, Korea (the Republic of)
  • Kang, Shin-Wook, College of Medicine, Institute of Kidney Disease Research, Yonsei University, Seoul, Korea (the Republic of)
Background

There are substantial differences in public health issues between men and women. However, longitudinal studies of the relationship between sex disparities and incident chronic kidney disease (CKD) are scarce. In this study, we aimed to evaluate the association between sex disparities and incident CKD in healthy adults with normal baseline kidney function.

Methods

We analyzed a total of 10.8 million adults who underwent National Health Insurance Service health examinations between 2009−2015. The outcome of interest was incident CKD, defined as de novo development of eGFR <60 mL/min per 1.73m2 (definition 1) or ≥25% decline in eGFR from the baseline values accompanied by eGFR <60 mL/min/1.73m2 (definition 2).

Results

In this large national cohort comprised of 10.8 million healthy Korean adults who had eGFR ≥60 ml/min per 1.73 m2, there were a total of 178,966 (1.66%) and 81,737 (0.76%) incident CKD events according to each CKD definitions, respectively, during a median follow-up of 4.8 years. Multivariable-adjusted Cox model showed that women were associated with significantly lower risk of incident CKD compared with men: adjusted hazard ratios (95% confidence intervals) for women (versus men) were 0.85 (0.84-0.86) and 0.86 (0.85-0.88) in models using CKD definition 1 and 2, respectively. These associations were robust irrespective of comorbid conditions, residential area, health behaviors, and use of antihypertensive drugs or statins. However, in elderly people aged ≥60 years, the risk of CKD was comparable between men and women.

Conclusion

In this large nationwide cohort, women had lower risk of CKD than men among healthy Korean adults.