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Abstract: FR-PO856

Long-Term Exposure to Air Pollution and Increased Risk of Membranous Nephrology in China

Session Information

Category: Glomerular Diseases

  • 1203 Glomerular Diseases: Clinical, Outcomes, and Trials

Authors

  • Hou, Fan Fan, Renal Division, Nanfang Hospital, Southern Medical University; National Clinical Research Center for Kidney Disease, Guangzhou, China
  • Xu, Xin, Renal Division, Nanfang Hospital, Southern Medical University; National Clinical Research Center for Kidney Disease, Guangzhou, China
  • Zhou, Liping, Renal Division, Nanfang Hospital, Southern Medical University; National Clinical Research Center for Kidney Disease, Guangzhou, China
  • Nie, Sheng, Renal Division, Nanfang Hospital, Southern Medical University; National Clinical Research Center for Kidney Disease, Guangzhou, China
  • Wang, Guobao, Renal Division, Nanfang Hospital, Southern Medical University; National Clinical Research Center for Kidney Disease, Guangzhou, China
  • Yue, Shuling, Guangzhou KingMed Diagnostics, Guangzhou, China
Background

We have previously shown that long-term exposure to PM2.5 was associated with an increased risk of membranous nephrology(MN) in a large renal biopsy series in China,which partly accounted for the doubling of MN in patients with renal biopsy during the last decade.Due to limitation of the data,we were not able to assess the effect of the components of air pollution and to distinguish MN by presence and absence of PLA2R antigen in the tissue.

Methods

In the current study,we analyzed 94,388 renal biopsies conducted at 1,205 hospitals spanning 262 cities in China from 2015 to 2018,of which 31,481(33.35%) were diagnosed as primary MN. We obtained the daily air pollution data of each participating city from the Ministry of Ecology and Environment of China. We examined the association between the year-average exposure of each component of air pollution and the risk of MN in the biopsy series using a generalized additive model adjusting for age,gender,and biopsy indication.

Results

Higher exposure to each component was associated with increased risk of MN, thought the relationship appeared to be non-linear for PM2.5 and linear for CO, NO2, O3, PM10, and SO2(Figure 1). Among the cases with primary MN, 7,947 had PLA2R test in the biopsy tissue, and the city-specific rate varied greatly, ranging from 73.68% to 88.26%.The overall PLA2R positive rate was 80.29%.Similarly,higher exposure to each component was associated with increased risk of PLA2R-related MN,thought the relationship appeared to be non-linear for CO, NO2 and linear for PM10, PM2.5, O3, and SO2(Figure 2).

Conclusion

In conclusion, long-term exposure to PM2.5,PM10,NO2,SO2,CO,O3 in ambient air was associated with an increased risk of MN in patients with renal biopsy as well as with an increased presence of PLA2R antigen in patients with MN.