Abstract: SA-PO923
Intraventricular Septum Thickness (IVST) Increases Depending on the Decline of eGFR in AL Renal Amyloidosis
Session Information
- CKD: Clinical, Outcomes, Trials - III
November 09, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2102 CKD (Non-Dialysis): Clinical, Outcomes, and Trials
Authors
- Nishi, Shinichi, Kobe University Graduate School of Medicine, Kobe, Japan
- Fujii, Hideki, Kobe University Graduate School of Medicine, Kobe, Japan
- Goto, Shunsuke, Kobe University Graduate School of Medicine, Kobe, Japan
- Kono, Keiji, Kobe University Graduate School of Medicine, Kobe, Japan
- Watanabe, Kentaro, Kobe University Graduate School of Medicine, Kobe, Japan
Background
In advanced AL amyloidosis, cardiac walls show thickening and cardiac functions reveal deterioration. It is unclear whether renal dysfunction and hypertension affect cardiac walls and functions in AL amyloidosis. We aimed to study the relationship between CKD progression and the ultrasound cardiac parameters in patients with AL amyloidosis.
Methods
The Amyloidosis Research Group, supported by funds from the Ministry of Health, Labour and Welfare in Japan surveyed the patients with AL amyloidosis in 2015. We could collected clinical data concerning renal and cardiac functions from 353 cases. Two hundred forty patients had positive urine protein and 113 patients had negative urine protein.
Results
In urine protein positive group, eGFR showed a significant negative correlation with IVST and LVPWT (p<0.05), while did not with LAD, EF, and E/e’. The cardiac ultrasound parameters showed no significant differences between hypertension positive and negative groups. Multiple linear regression analysis showed IVST and LVPWT showed independently significant relationship with eGFR but not with hypertension. In urine protein negative group, eGFR showed no significant relationship with IVST and LVPWT. IVST and LVPWT showed significant differences between hypertension positive and negative group. The both parameters were significantly thicker in hypertension positive group (p<0.05).
Conclusion
In AL amyloidosis with urine protein, IVST and LVPWT became significantly thick according to the decline of renal function but the thickening of cardiac walls had no relationship with hypertension.. In urine protein negative group, these results were up and down. From the present data, we suspected the cardiac amyloid deposition might begin from the appearance of urine protein in AL amyloidosis. The progression of cardiac wall thickening might not depend on hypertension in AL renal amyloidosis.
Funding
- Government Support - Non-U.S.