Kidney Week

Abstract: TH-PO1166

Living Kidney Donors with Metabolic Risk Increased in South Korea

Session Information

• Transplantation: Clinical - Pretransplant Management
  November 07, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Transplantation

• 1902 Transplantation: Clinical

Authors

• Kang, Eunjeong, Keimyung University Dongsan Hospital, Daegu, Korea (the Republic of)

Eunjeong Kang,

• Park, Sehoon, Seoul National University College of Medicine, Seoul, Korea (the Republic of)

Sehoon Park,

• Kim, Yaerim, Keimyung University Dongsan Hospital, Daegu, Korea (the Republic of)

Yaerim Kim,

• Han, Miyeun, Pusan National University Hospital, Busan, Korea (the Republic of)

Miyeun Han,

• Lee, Jung Pyo, Seoul National University Boramae Medical Center, Seoul, Korea (the Republic of)

Jung Pyo Lee,

• Jeong, Jong Cheol, Ajou University Hospital, Suwon, Korea (the Republic of)

Jong Cheol Jeong,

• Chae, Dong-Wan, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea (the Republic of)

Dong-Wan Chae,

• Kim, Yon Su, Seoul National University College of Medicine, Seoul, Korea (the Republic of)

Yon Su Kim,

• Lee, Hajeong, Seoul National University College of Medicine, Seoul, Korea (the Republic of)

Hajeong Lee,

Background

Living donor kidney transplantation is the best treatment option with regard to patients’ prognosis for end-stage renal disease(ESRD) if only donor safety is secured. Hence, it is worthwhile to review of epidemiology of living kidney donors nationwide and living kidney donors with higher risk including metabolic syndrome.

Methods

Living kidney donors in 4 national university hospital of South Korea were enrolled. Demographic and laboratory data were collected. Hyperuricemia was defined as uric acid greater than 7 mg/dL. Underweight, overweight and obesity were defined as body mass index (BMI) <18.5, 25-29.9 and ≥30 kg/m², respectively. The era of the transplant was classified into 4 groups with quartiles of the number of donors as follows; 1982-2001, 2002-2009, 2010-2014, and 2015-2019.

Results

A total of 2,002 living kidney donors were enrolled and the number of living kidney transplants increased rapidly from 109 in the 1980s to 987 in the 2010s. Mean age were 42.6±11.5 years and 45.9% were male. The most common donor-recipient relationship was parent-child (39.5%), followed by siblings(30.6%), and husbands-wife(21.1%). Husband-wife relationship was increased over time(4.5% at 1982-2001, 34.7% at 2015-2019). The proportion of old donors(age >60 years) were increased across the era of transplant(3.7% at 1982-2001, 11.2% at 2015-2019). Mean estimated glomerular filtration rate(eGFR) was 90.9±20.5 and 98.8±16.3 mL/min/1.73m² by MDRD and CKD-EPI equation, respectively. The baseline eGFR were increased in course of time. Patients with diabetes and impaired glucose tolerance (IGT) were 5(0.25%) and 37(1.85%), respectively. Patients who had history of dyslipidemia accounted for 18% and mean total cholesterol value tended to increase over time. Mean BMI was 23.75±3.39 kg/m^2. Overweight and obese donors were 527(27.05%) and 93(4.77%), respectively. The proportion of donors with IGT, dyslipidemia, and overweight /obesity tended to increase over time.

Conclusion

The factors related to metabolic syndrome generally tended to increase in kidney donor over time, and living kidney transplants between couples increased. Whether the donors’ metabolic syndrome affect post-donation morbidity or not should be further evaluated.

Funding

• Government Support - Non-U.S.