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Kidney Week

Abstract: TH-PO060

Red Blood Cell Distribution Width and Risk for Contrast-Induced AKI After Percutaneous Coronary Intervention

Session Information

Category: Acute Kidney Injury

  • 101 AKI: Epidemiology, Risk Factors, and Prevention

Authors

  • Yamada, Takayuki, Mount Sinai Beth Israel, New York, United States
  • Wakui, Hiromichi, Yokohama City University, Yokohama, Japan
  • Tamura, Kouichi, Yokohama City University, Yokohama, Japan
  • Burger, Alfred, Mount Sinai Beth Israel, New York, New York, United States
  • Coca, Steven G., Icahn School of Medicine at Mount Sinai, New York, New York, United States
Background

Contrast-induced acute kidney injury (CI-AKI) is a major complication following percutaneous coronary intervention (PCI) and is associated with greater morbidity and mortality. Accumulating evidence suggests that inflammation and oxidative stress play an important role in the development of CI-AKI. Red blood cell distribution width (RDW) is a possible marker of oxidative stress and inflammation. In this study, we performed a systematic review and meta-analysis to investigate the association between RDW levels and CI-AKI after PCI.

Methods

We assessed clinical studies through Pubmed, Embase, and the Cochrane Library that investigated the association between RDW and a risk of CI-AKI in patients after PCI up to April 2019. The primary outcome was CI-AKI.

Results

A total of five observational studies met the inclusion criteria. The pooled population consisted of 2,432 patients. Using multivariable logistic regression analysis, increased RDW (cutoff between 13.25 to 15.2) was independently associated with greater risk for CI-AKI after PCI (pooled adjusted odds ratio (OR), 1.48; 95% confidence interval (CI), 1.32 to 1.67; I2 = 0%) (Figure). Subgroup analysis in patients with ST elevation myocardial infarction demonstrated a similar tendency (OR, 1.58; 95% CI, 1.35 to 1.85; I2 = 0%).

Conclusion

Increased RDW is associated with increased risk of CI-AKI after PCI. Further studies are needed to assess the utility of RDW as a risk-stratifier for CIN.